DegronMD - Q6P995(FAM171B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L470I	TCGA-19-5956	GBM	TCGA	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.25
p.L470I	DO13863	GBM	ICGC	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.25
p.N476S	TCGA-4R-AA8I	LIHC	TCGA	NQNNYSRNP	CBL_PTK	473:481	Mutation altering degron motif	0.5958
p.N476S	DO49657	LIHC	ICGC	NQNNYSRNP	CBL_PTK	473:481	Mutation altering degron motif	0.5958
p.V641L	TCGA-55-6970	LUAD	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.5654
p.V641L	DO24421	LUAD	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.5654
p.T636I	TCGA-61-2110	OV	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.1944
p.T636I	DO27979	OV	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.1944
p.V489A	TCGA-AA-3663	COAD	TCGA	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.1111
p.V489A	DO9346	COAD	ICGC	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.1111
p.M643T	TCGA-AA-A022	COAD	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.6312
p.M643T	DO10647	COAD	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.6312
p.A640V	TCGA-AP-A0LM	UCEC	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.3056
p.A640V	DO43306	UCEC	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.3056
p.G652R	TCGA-D1-A2G0	UCEC	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.2222
p.G652R	DO43049	UCEC	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.2222
p.P645Q	TCGA-EE-A3AC	SKCM	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7035
p.P645Q	DO37631	SKCM	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7035
p.Q656H	TCGA-NC-A5HD	LUSC	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.1111
p.Q656H	DO219184	LUSC	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.1111
p.L650R	TCGA-VQ-A91S	STAD	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.2778
p.L650R	DO222352	STAD	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.2778
p.D466N	DO234208	ESAD	ICGC	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.1389
p.S648L	DO228583	GACA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7667
p.S648L	DO233203	GACA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7667
p.S648L	DO230555	PRAD	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7667
p.S648L	SIDM00214	Colorectal Carcinoma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7667
p.S648L	ACH-000955	Colon/Colorectal Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7667
p.S648L	SNU-407	large intestine	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7667
p.V631I	DO233634	GACA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0556
p.V631I	SIDM00143	Small Cell Lung Carcinoma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0556
p.V631I	ACH-000803	Lung Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0556
p.V631I	COLO-668	lung	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0556
p.G635V	DO229019	LICA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.1667
p.T644A	DO50865	LICA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.7139
p.S654L	DO222595	MELA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.1667
p.S654L	DO218849	SKCA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.1667
p.S632F	SIDM01483	Melanoma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0833
p.S632F	ACH-000582	Skin Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0833
p.S632F	COLO-741	large intestine	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0833
p.S478A	SIDM00284	Melanoma	GDSC	NQNNYSRNP	CBL_PTK	473:481	Mutation altering degron motif	0.7588
p.S478A	COLO-679	skin	COSMIC	NQNNYSRNP	CBL_PTK	473:481	Mutation altering degron motif	0.7588
p.L650I	SIDM00391	Plasma Cell Myeloma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.2778
p.L650I	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.2778
p.V472F	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.3056
p.V472F	ACH-002337	Lung Cancer	CCLE	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.3056
p.T482I	SIDM01074	Glioblastoma	GDSC	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.3056
p.T482I	ACH-000102	Brain Cancer	CCLE	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.3056
p.T482I	GMS-10	central nervous system	COSMIC	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.3056
p.G490V	SIDM01316	Ewing's Sarcoma	GDSC	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.0833
p.G490V	ACH-000041	Bone Cancer	CCLE	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.0833
p.L658H	SIDM01750	Melanoma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0556
p.L658H	ACH-000801	Skin Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0556
p.D466H	ACH-000436	Myeloma	CCLE	NQNNYSRNP	CBL_PTK	473:481	Mutation rewiring degron network	0.1389
p.S647L	ACH-000578	Lung Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation altering degron motif	0.6556
p.L658I	ACH-000872	Lung Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.0556
p.G652E	ACH-002396	Bone Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.2222
p.G652E	Sarc9371	bone	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	641:648	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM171B

UniProt ID: Q6P995

Entrez ID: 165215

Protein name: Protein FAM171B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM171B in