DegronMD

Uniprot ID: Q6P995

Source protein: Protein FAM171B

Source gene: FAM171B

Class: DEG_SCF_FBW7_1

Location: 641:648

E3 ligase: FBXW7

DEGRON score: 0.9741

ASA_SCORE: 76.5375

COIL: 0.7491

CONS_SCORE: 0.5617

DSS_SCORE: 0.3521

HELIX: 0.1689

FCONS_SCORE: 1.0781

RIG_SCORE: 0.8017

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V641L	TCGA-55-6970	LUAD	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	0.5654
p.V641L	DO24421	LUAD	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.5654
p.T636I	TCGA-61-2110	OV	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	0.1944
p.T636I	DO27979	OV	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.1944
p.M643T	TCGA-AA-A022	COAD	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	0.6312
p.M643T	DO10647	COAD	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.6312
p.A640V	TCGA-AP-A0LM	UCEC	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	0.3056
p.A640V	DO43306	UCEC	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.3056
p.G652R	TCGA-D1-A2G0	UCEC	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	0.2222
p.G652R	DO43049	UCEC	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.2222
p.P645Q	TCGA-EE-A3AC	SKCM	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	0.7035
p.P645Q	DO37631	SKCM	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.7035
p.Q656H	TCGA-NC-A5HD	LUSC	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	0.1111
p.Q656H	DO219184	LUSC	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.1111
p.L650R	TCGA-VQ-A91S	STAD	TCGA	VVMTPFSS	DEG_SCF_FBW7_1	0.2778
p.L650R	DO222352	STAD	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.2778
p.S648L	DO228583	GACA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.7667
p.S648L	DO233203	GACA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.7667
p.S648L	DO230555	PRAD	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.7667
p.S648L	SIDM00214	Colorectal Carcinoma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	0.7667
p.S648L	ACH-000955	Colon/Colorectal Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	0.7667
p.S648L	SNU-407	large_intestine	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	0.7667
p.V631I	DO233634	GACA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.0556
p.V631I	SIDM00143	Small Cell Lung Carcinoma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	0.0556
p.V631I	ACH-000803	Lung Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	0.0556
p.V631I	COLO-668	lung	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	0.0556
p.G635V	DO229019	LICA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.1667
p.T644A	DO50865	LICA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.7139
p.S654L	DO222595	MELA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.1667
p.S654L	DO218849	SKCA	ICGC	VVMTPFSS	DEG_SCF_FBW7_1	0.1667
p.S632F	SIDM01483	Melanoma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	0.0833
p.S632F	ACH-000582	Skin Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	0.0833
p.S632F	COLO-741	large_intestine	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	0.0833
p.L650I	SIDM00391	Plasma Cell Myeloma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	0.2778
p.L650I	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	0.2778
p.L658H	SIDM01750	Melanoma	GDSC	VVMTPFSS	DEG_SCF_FBW7_1	0.0556
p.L658H	ACH-000801	Skin Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	0.0556
p.S647L	ACH-000578	Lung Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	0.6556
p.L658I	ACH-000872	Lung Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	0.0556
p.G652E	ACH-002396	Bone Cancer	CCLE	VVMTPFSS	DEG_SCF_FBW7_1	0.2222
p.G652E	Sarc9371	bone	COSMIC	VVMTPFSS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVMTPFSS

Degron related mutations and impact score

Drug responses associated with FAM171B mutations

All proteins holding degron of VVMTPFSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P995	Protein FAM171B	DEG_SCF_FBW7_1	641:648	VVMTPFSS	FBXW7	0.9741	More...