DegronMD

Uniprot ID: Q86YS7

Source protein: C2 domain-containing protein 5

Source gene: C2CD5

Class: CBL_PTK

Location: 289:296

E3 ligase: CBL

DEGRON score: 0.7449

ASA_SCORE: 96.3375

COIL: 0.8861

CONS_SCORE: 0.3113

DSS_SCORE: 0.6307

HELIX: 0.0586

FCONS_SCORE: 0.9118

RIG_SCORE: 0.6455

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q290E	TCGA-A8-A093	BRCA	TCGA	NQTYSFSP	CBL_PTK	0.5633
p.Q290E	DO4161	BRCA	ICGC	NQTYSFSP	CBL_PTK	0.5633
p.N289K	TCGA-AX-A05Z	UCEC	TCGA	NQTYSFSP	CBL_PTK	0.6918
p.N289K	DO222798	COCA	ICGC	NQTYSFSP	CBL_PTK	0.6918
p.N289K	DO40884	UCEC	ICGC	NQTYSFSP	CBL_PTK	0.6918
p.S297F	TCGA-AY-A54L	COAD	TCGA	NQTYSFSP	CBL_PTK	0.75
p.S297F	DO44091	COAD	ICGC	NQTYSFSP	CBL_PTK	0.75
p.P286T	TCGA-B5-A11E	UCEC	TCGA	NQTYSFSP	CBL_PTK	0.25
p.P286T	DO41644	UCEC	ICGC	NQTYSFSP	CBL_PTK	0.25
p.Q290K	DO228952	LICA	ICGC	NQTYSFSP	CBL_PTK	0.5833
p.P283T	DO229024	LICA	ICGC	NQTYSFSP	CBL_PTK	0.1667
p.A289D	DO229027	LICA	ICGC	NQTYSFSP	CBL_PTK	0.7793
p.A289G	DO23134	LINC	ICGC	NQTYSFSP	CBL_PTK	0.754
p.Y292F	DO231906	LINC	ICGC	NQTYSFSP	CBL_PTK	0.8639
p.Y292F	SIDM00435	Acute Myeloid Leukemia	GDSC	NQTYSFSP	CBL_PTK	0.8639
p.Y292F	ACH-000369	Leukemia	CCLE	NQTYSFSP	CBL_PTK	0.8639
p.Y292F	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	NQTYSFSP	CBL_PTK	0.8639
p.T290I	DO220239	SARC	ICGC	NQTYSFSP	CBL_PTK	0.7078
p.G282R	SIDM02057	Colorectal Carcinoma	GDSC	NQTYSFSP	CBL_PTK	0.1389
p.S293F	SIDM00080	Melanoma	GDSC	NQTYSFSP	CBL_PTK	0.9093
p.S293F	ACH-000730	Skin Cancer	CCLE	NQTYSFSP	CBL_PTK	0.9093
p.S293F	SK-MEL-5	skin	COSMIC	NQTYSFSP	CBL_PTK	0.9093
p.I286V	SIDM01129	Small Cell Lung Carcinoma	GDSC	NQTYSFSP	CBL_PTK	0.25
p.I286V	NCI-H524	lung	COSMIC	NQTYSFSP	CBL_PTK	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YS7	C2 domain-containing protein 5	CBL_PTK	289:296	NQTYSFSP	CBL	0.7449	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons