DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NRDSLSNVI
Uniprot ID:
Q8NDH2
Source protein:
Leucine-rich repeat transmembrane protein CCDC168
Source gene:
CCDC168
Class:
DEG_APCC_DBOX_1
Location:
3775:3783
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7057
ASA_SCORE:
85.4111
COIL:
0.6447
CONS_SCORE:
0
DSS_SCORE:
0.3708
HELIX:
0.1822
FCONS_SCORE:
0
RIG_SCORE:
0.7155
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CCDC168 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NRDSLSNVI
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
DEG_APCC_DBOX_1
3775:3783
NRDSLSNVI
APC,CDC20,FZR1
0.7057
More...