DegronMD

Uniprot ID: Q69YN4

Source protein: Protein virilizer homolog

Source gene: VIRMA

Class: DEG_APCC_DBOX_1

Location: 1748:1756

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9876

ASA_SCORE: 84.5444

COIL: 0.9533

CONS_SCORE: 0.3429

DSS_SCORE: 0.7271

HELIX: 0.0296

FCONS_SCORE: 0.9754

RIG_SCORE: 0.6154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1741H	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRGPLPPLR	DEG_APCC_DBOX_1	0.1389
p.R1741H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	NRGPLPPLR	DEG_APCC_DBOX_1	0.1389
p.R1741H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	NRGPLPPLR	DEG_APCC_DBOX_1	0.1389
p.R1764C	SIDM00892	Breast Carcinoma	GDSC	NRGPLPPLR	DEG_APCC_DBOX_1	0.1111
p.R1764C	BT-483	breast	COSMIC	NRGPLPPLR	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q69YN4	Protein virilizer homolog	DEG_APCC_DBOX_1	1748:1756	NRGPLPPLR	APC,CDC20,FZR1	0.9876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons