DegronMD

Uniprot ID: Q6P0N0

Source protein: Mis18-binding protein 1

Source gene: MIS18BP1

Class: DEG_APCC_DBOX_1

Location: 864:872

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9138

ASA_SCORE: 88.6889

COIL: 0.8123

CONS_SCORE: 0.3208

DSS_SCORE: 0.4117

HELIX: 0.0953

FCONS_SCORE: 0.7903

RIG_SCORE: 0.7788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H866Y	TCGA-AJ-A3BG	UCEC	TCGA	NRHPLECLP	DEG_APCC_DBOX_1	0.6118
p.H866Y	DO42633	UCEC	ICGC	NRHPLECLP	DEG_APCC_DBOX_1	0.6118
p.D861H	TCGA-C8-A8HQ	BRCA	TCGA	NRHPLECLP	DEG_APCC_DBOX_1	0.25
p.D861H	DO1071	BRCA	ICGC	NRHPLECLP	DEG_APCC_DBOX_1	0.25
p.D861H	DO219623	BRCA	ICGC	NRHPLECLP	DEG_APCC_DBOX_1	0.25
p.P867T	TCGA-CH-5762	PRAD	TCGA	NRHPLECLP	DEG_APCC_DBOX_1	0.5919
p.P867T	DO36228	PRAD	ICGC	NRHPLECLP	DEG_APCC_DBOX_1	0.5919
p.Q876P	TCGA-D1-A103	UCEC	TCGA	NRHPLECLP	DEG_APCC_DBOX_1	0.2222
p.Q876P	DO42312	UCEC	ICGC	NRHPLECLP	DEG_APCC_DBOX_1	0.2222
p.C870Y	TCGA-PJ-A5Z8	KIRP	TCGA	NRHPLECLP	DEG_APCC_DBOX_1	0.5976
p.C870Y	DO44480	KIRP	ICGC	NRHPLECLP	DEG_APCC_DBOX_1	0.5976
p.E882Q	DO23490	LINC	ICGC	NRHPLECLP	DEG_APCC_DBOX_1	0.0556
p.P867L	SIDM00238	Ovarian Carcinoma	GDSC	NRHPLECLP	DEG_APCC_DBOX_1	0.6471
p.P867L	ACH-000947	Ovarian Cancer	CCLE	NRHPLECLP	DEG_APCC_DBOX_1	0.6471
p.P867L	OVK-18	ovary	COSMIC	NRHPLECLP	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P0N0	Mis18-binding protein 1	DEG_APCC_DBOX_1	864:872	NRHPLECLP	APC,CDC20,FZR1	0.9138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons