DegronMD

Uniprot ID: Q9NQR1

Source protein: N-lysine methyltransferase KMT5A

Source gene: KMT5A

Class: DEG_CRL4_CDT2_1

Location: 219:231

E3 ligase: DTL

DEGRON score: 0.9965

ASA_SCORE: 95.3538

COIL: 0.6734

CONS_SCORE: 0.661

DSS_SCORE: 0.6351

HELIX: 0.2599

FCONS_SCORE: 1.3114

RIG_SCORE: 0.7368

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K226T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_1	0.7306
p.K226T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_2	0.7306
p.K226T	NCI-H1155	lung	COSMIC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_1	0.7306
p.K226T	NCI-H1155	lung	COSMIC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_2	0.7306
p.D224Y	PCI-38	upper_aerodigestive_tract	COSMIC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_1	0.7325
p.D224Y	PCI-38	upper_aerodigestive_tract	COSMIC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_2	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQR1	N-lysine methyltransferase KMT5A	DEG_CRL4_CDT2_1	219:231	NRKLTDFYPVRRS	DTL	0.9965	More...
Q9NQR1	N-lysine methyltransferase KMT5A	DEG_CRL4_CDT2_2	219:231	NRKLTDFYPVRRS	DTL	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons