DegronMD - Q9NQR1(KMT5A)

KMT5A

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K226T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_1	219:231	Mutation altering degron motif	0.7306
p.K226T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_2	219:231	Mutation altering degron motif	0.7306
p.K226T	NCI-H1155	lung	COSMIC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_1	219:231	Mutation altering degron motif	0.7306
p.K226T	NCI-H1155	lung	COSMIC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_2	219:231	Mutation altering degron motif	0.7306
p.T175M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPKTPPSS	DEG_SCF_FBW7_1	178:185	Mutation rewiring degron network	0.25
p.T175M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPKTPPSS	DEG_SCF_FBW7_1	178:185	Mutation rewiring degron network	0.25
p.R179C	SIDM01451	Pancreatic Carcinoma	GDSC	PPKTPPSS	DEG_SCF_FBW7_1	178:185	Mutation altering degron motif	0.8301
p.D224Y	PCI-38	upper aerodigestive tract	COSMIC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_1	219:231	Mutation altering degron motif	0.7325
p.D224Y	PCI-38	upper aerodigestive tract	COSMIC	NRKLTDFYPVRRS	DEG_CRL4_CDT2_2	219:231	Mutation altering degron motif	0.7325

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*NOTE: the Kaplan plots were collected from OncoLnc