DegronMD

Uniprot ID: Q9NQR1

Source protein: N-lysine methyltransferase KMT5A

Source gene: KMT5A

Class: DEG_SCF_FBW7_1

Location: 178:185

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 96.9125

COIL: 0.9558

CONS_SCORE: 0.3912

DSS_SCORE: 0.7218

HELIX: 0.0301

FCONS_SCORE: 0.9969

RIG_SCORE: 0.5647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T175M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPKTPPSS	DEG_SCF_FBW7_1	0.25
p.T175M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPKTPPSS	DEG_SCF_FBW7_1	0.25
p.R179C	SIDM01451	Pancreatic Carcinoma	GDSC	PPKTPPSS	DEG_SCF_FBW7_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQR1	N-lysine methyltransferase KMT5A	DEG_SCF_FBW7_1	178:185	PPKTPPSS	FBXW7	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons