DegronMD

Uniprot ID: Q8N865

Source protein: Uncharacterized protein C7orf31

Source gene: C7orf31

Class: DEG_APCC_DBOX_1

Location: 341:349

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6797

ASA_SCORE: 96.7778

COIL: 0.6242

CONS_SCORE: 0.2855

DSS_SCORE: 0.3712

HELIX: 0.3257

FCONS_SCORE: 1.0294

RIG_SCORE: 0.7889

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R337Q	TCGA-BS-A0UF	UCEC	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	0.2222
p.R337Q	DO41488	UCEC	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.2222
p.R354C	TCGA-C5-A7CH	CESC	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	0.1944
p.R354C	DO49885	CESC	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.1944
p.Q340H	TCGA-CD-5813	STAD	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	0.3056
p.Q340H	DO38259	STAD	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.3056
p.G333E	TCGA-CN-5369	HNSC	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	0.1111
p.G333E	DO16069	HNSC	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.1111
p.S355F	TCGA-EE-A29D	SKCM	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	0.1667
p.S355F	DO38123	SKCM	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.1667
p.R343C	DO228927	COCA	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.719
p.R343H	DO218693	GACA	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.7133
p.R342Q	DO233869	GACA	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.7329
p.R342Q	SIDM00576	Acute Myeloid Leukemia	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	0.7329
p.I348T	DO233867	GACA	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.7078
p.R334Q	DO23546	LIRI	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	0.1389
p.R334Q	SIDM02026	Colorectal Carcinoma	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	0.1389
p.A347V	SIDM02035	Colorectal Carcinoma	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	0.5825
p.P353R	SIDM01044	Other Solid Cancers	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	0.2222
p.P353R	ACH-000585	Lung Cancer	CCLE	NRRSLEAIV	DEG_APCC_DBOX_1	0.2222
p.R354S	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	0.1944
p.R354S	ACH-000951	Lung Cancer	CCLE	NRRSLEAIV	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N865	Uncharacterized protein C7orf31	DEG_APCC_DBOX_1	341:349	NRRSLEAIV	APC,CDC20,FZR1	0.6797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons