DegronMD - Q8N865(C7orf31)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M516I	TCGA-44-A4SU	LUAD	TCGA	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1667
p.M516I	DO24507	LUAD	ICGC	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1667
p.P210L	TCGA-A5-A0G2	UCEC	TCGA	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation altering degron motif	0.6471
p.P210L	DO41235	UCEC	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation altering degron motif	0.6471
p.R203I	TCGA-AN-A046	BRCA	TCGA	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation altering degron motif	0.8102
p.R203I	DO1285	BRCA	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation altering degron motif	0.8102
p.R337Q	TCGA-BS-A0UF	UCEC	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.R337Q	DO41488	UCEC	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.R354C	TCGA-C5-A7CH	CESC	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1944
p.R354C	DO49885	CESC	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1944
p.Q340H	TCGA-CD-5813	STAD	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.3056
p.Q340H	DO38259	STAD	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.3056
p.G333E	TCGA-CN-5369	HNSC	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1111
p.G333E	DO16069	HNSC	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1111
p.P201H	TCGA-DA-A1IB	SKCM	TCGA	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.3056
p.P201H	DO38033	SKCM	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.3056
p.S355F	TCGA-EE-A29D	SKCM	TCGA	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1667
p.S355F	DO38123	SKCM	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1667
p.R198K	DO48402	BLCA	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.2222
p.R343C	DO228927	COCA	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.719
p.R343H	DO218693	GACA	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.7133
p.R342Q	DO233869	GACA	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.7329
p.R342Q	SIDM00576	Acute Myeloid Leukemia	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.7329
p.I348T	DO233867	GACA	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.7078
p.P537H	DO228974	LICA	ICGC	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1389
p.L195F	DO48691	LIRI	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.1389
p.R334Q	DO23546	LIRI	ICGC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1389
p.R334Q	SIDM02026	Colorectal Carcinoma	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1389
p.P530S	DO222843	MELA	ICGC	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.5641
p.T219I	DO222843	MELA	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.0833
p.S192T	DO232838	NACA	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.0556
p.A347V	SIDM02035	Colorectal Carcinoma	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.5825
p.T197S	SIDM00855	Other Sarcomas	GDSC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.1944
p.T197S	SIDM00032	Bladder Carcinoma	GDSC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.1944
p.P353R	SIDM01044	Other Solid Cancers	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.P353R	ACH-000585	Lung Cancer	CCLE	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.E520K	SIDM00272	Breast Carcinoma	GDSC	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.E520K	SIDM01059	Melanoma	GDSC	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.E520K	ACH-000910	Breast Cancer	CCLE	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.E520K	ACH-000915	Skin Cancer	CCLE	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.I207N	SIDM00837	Colorectal Carcinoma	GDSC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation altering degron motif	0.6169
p.I207N	ACH-000958	Colon/Colorectal Cancer	CCLE	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation altering degron motif	0.6169
p.T193P	SIDM00537	Colorectal Carcinoma	GDSC	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.0833
p.T193P	ACH-001345	Colon/Colorectal Cancer	CCLE	YRYELIDIP	DEG_APCC_DBOX_1	202:210	Mutation rewiring degron network	0.0833
p.R354S	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1944
p.R354S	ACH-000951	Lung Cancer	CCLE	NRRSLEAIV	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1944
p.G527A	ACH-001459	Colon/Colorectal Cancer	CCLE	TRPVLGWIP	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.6429

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C7orf31

UniProt ID: Q8N865

Entrez ID: 136895

Protein name: Uncharacterized protein C7orf31

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C7orf31 in