DegronMD

Uniprot ID: Q8N865

Source protein: Uncharacterized protein C7orf31

Source gene: C7orf31

Class: DEG_APCC_DBOX_1

Location: 522:530

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9788

ASA_SCORE: 68.0778

COIL: 0.8419

CONS_SCORE: 0.251

DSS_SCORE: 0.4392

HELIX: 0.0933

FCONS_SCORE: 0.9798

RIG_SCORE: 0.8027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M516I	TCGA-44-A4SU	LUAD	TCGA	TRPVLGWIP	DEG_APCC_DBOX_1	0.1667
p.M516I	DO24507	LUAD	ICGC	TRPVLGWIP	DEG_APCC_DBOX_1	0.1667
p.P537H	DO228974	LICA	ICGC	TRPVLGWIP	DEG_APCC_DBOX_1	0.1389
p.P530S	DO222843	MELA	ICGC	TRPVLGWIP	DEG_APCC_DBOX_1	0.5641
p.E520K	SIDM00272	Breast Carcinoma	GDSC	TRPVLGWIP	DEG_APCC_DBOX_1	0.2778
p.E520K	SIDM01059	Melanoma	GDSC	TRPVLGWIP	DEG_APCC_DBOX_1	0.2778
p.E520K	ACH-000910	Breast Cancer	CCLE	TRPVLGWIP	DEG_APCC_DBOX_1	0.2778
p.E520K	ACH-000915	Skin Cancer	CCLE	TRPVLGWIP	DEG_APCC_DBOX_1	0.2778
p.G527A	ACH-001459	Colon/Colorectal Cancer	CCLE	TRPVLGWIP	DEG_APCC_DBOX_1	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N865	Uncharacterized protein C7orf31	DEG_APCC_DBOX_1	522:530	TRPVLGWIP	APC,CDC20,FZR1	0.9788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons