DegronMD

Uniprot ID: Q8N865

Source protein: Uncharacterized protein C7orf31

Source gene: C7orf31

Class: DEG_APCC_DBOX_1

Location: 202:210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5264

ASA_SCORE: 62.8444

COIL: 0.4863

CONS_SCORE: 0.6192

DSS_SCORE: 0.3244

HELIX: 0.0588

FCONS_SCORE: 0.9172

RIG_SCORE: 0.8814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P210L	TCGA-A5-A0G2	UCEC	TCGA	YRYELIDIP	DEG_APCC_DBOX_1	0.6471
p.P210L	DO41235	UCEC	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	0.6471
p.R203I	TCGA-AN-A046	BRCA	TCGA	YRYELIDIP	DEG_APCC_DBOX_1	0.8102
p.R203I	DO1285	BRCA	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	0.8102
p.P201H	TCGA-DA-A1IB	SKCM	TCGA	YRYELIDIP	DEG_APCC_DBOX_1	0.3056
p.P201H	DO38033	SKCM	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	0.3056
p.R198K	DO48402	BLCA	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	0.2222
p.L195F	DO48691	LIRI	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	0.1389
p.T219I	DO222843	MELA	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	0.0833
p.S192T	DO232838	NACA	ICGC	YRYELIDIP	DEG_APCC_DBOX_1	0.0556
p.T197S	SIDM00855	Other Sarcomas	GDSC	YRYELIDIP	DEG_APCC_DBOX_1	0.1944
p.T197S	SIDM00032	Bladder Carcinoma	GDSC	YRYELIDIP	DEG_APCC_DBOX_1	0.1944
p.I207N	SIDM00837	Colorectal Carcinoma	GDSC	YRYELIDIP	DEG_APCC_DBOX_1	0.6169
p.I207N	ACH-000958	Colon/Colorectal Cancer	CCLE	YRYELIDIP	DEG_APCC_DBOX_1	0.6169
p.T193P	SIDM00537	Colorectal Carcinoma	GDSC	YRYELIDIP	DEG_APCC_DBOX_1	0.0833
p.T193P	ACH-001345	Colon/Colorectal Cancer	CCLE	YRYELIDIP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N865	Uncharacterized protein C7orf31	DEG_APCC_DBOX_1	202:210	YRYELIDIP	APC,CDC20,FZR1	0.5264	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons