DegronMD

Uniprot ID: Q8TC71

Source protein: Mitochondria-eating protein

Source gene: SPATA18

Class: DEG_APCC_DBOX_1

Location: 289:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8367

ASA_SCORE: 88.6556

COIL: 0.6056

CONS_SCORE: 0.6535

DSS_SCORE: 0.5073

HELIX: 0.3563

FCONS_SCORE: 1.1761

RIG_SCORE: 0.6941

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R285K	TCGA-50-5932	LUAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.2222
p.R298S	TCGA-86-7954	LUAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.3056
p.A297V	TCGA-97-8552	LUAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.5825
p.L303V	TCGA-A5-A0G2	UCEC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.1667
p.R290L	TCGA-BA-6868	HNSC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.8428
p.R290L	DO228974	LICA	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	0.8428
p.L302F	TCGA-BB-7870	HNSC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.1944
p.P286Q	TCGA-BR-A4QL	STAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.25
p.R290H	TCGA-BS-A0TC	UCEC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.8244
p.R290H	SIDM00217	Colorectal Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.8244
p.R290H	SIDM01611	Endometrial Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.8244
p.R290H	SNU-1040	large_intestine	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	0.8244
p.R284W	TCGA-CC-A7IK	LIHC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.1944
p.S304P	TCGA-CM-5861	COAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.1389
p.R305W	TCGA-D3-A51G	SKCM	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.1111
p.S291C	TCGA-MV-A51V	BLCA	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.643
p.S294F	TCGA-WE-A8ZT	SKCM	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	0.6871
p.R282C	DO233652	GACA	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	0.25
p.D294Y	DO23556	LUAD	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	0.7325
p.R282H	DO27849	MALY	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	0.25
p.A285V	DO38380	STAD	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	0.2222
p.R301Q	DO47925	STAD	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	0.2222
p.R301W	DO43122	UCEC	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	0.2222
p.D294N	DO41903	UCEC	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	0.6932
p.S287F	SIDM00277	Acute Myeloid Leukemia	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.2778
p.S287F	ACH-000198	Leukemia	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	0.2778
p.S287F	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	0.2778
p.A280T	SIDM00690	Head and Neck Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.0833
p.A280T	SIDM00596	Endometrial Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.0833
p.P286A	SIDM00929	Chondrosarcoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.25
p.P286A	SIDM00118	Colorectal Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.25
p.K292N	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.5806
p.K292N	ACH-000900	Lung Cancer	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	0.5806
p.K292N	NCI-H23	lung	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	0.5806
p.V281I	SIDM00954	Breast Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.1111
p.V281I	COLO-824	breast	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	0.1111
p.R298C	SIDM00951	T-Lymphoblastic Leukemia	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.3056
p.R298C	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	0.3056
p.T279I	SIDM01424	B-Lymphoblastic Leukemia	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	0.0556
p.L283V	ACH-000323	Brain Cancer	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	0.1667
p.L283V	42-MG-BA	central_nervous_system	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	0.1667
p.R282P	ACH-000843	Lung Cancer	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	0.25
p.R282P	HARA	lung	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	0.25
p.D284N	ACH-000990	Endometrial/Uterine Cancer	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRSKLSNVA

Degron related mutations and impact score

Drug responses associated with SPATA18 mutations

All proteins holding degron of NRSKLSNVA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TC71	Mitochondria-eating protein	DEG_APCC_DBOX_1	289:297	NRSKLSNVA	APC,CDC20,FZR1	0.8367	More...