DegronMD - Q8TC71(SPATA18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R285K	TCGA-50-5932	LUAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.2222
p.R298S	TCGA-86-7954	LUAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.A297V	TCGA-97-8552	LUAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.5825
p.D107N	TCGA-99-8025	LUAD	TCGA	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.1944
p.D107N	DO24255	LUAD	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.1944
p.L303V	TCGA-A5-A0G2	UCEC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.R290L	TCGA-BA-6868	HNSC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.8428
p.R290L	DO228974	LICA	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.8428
p.L302F	TCGA-BB-7870	HNSC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1944
p.P286Q	TCGA-BR-A4QL	STAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.25
p.R290H	TCGA-BS-A0TC	UCEC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.8244
p.R290H	SIDM00217	Colorectal Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.8244
p.R290H	SIDM01611	Endometrial Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.8244
p.R290H	SNU-1040	large intestine	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.8244
p.R284W	TCGA-CC-A7IK	LIHC	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1944
p.S304P	TCGA-CM-5861	COAD	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1389
p.R305W	TCGA-D3-A51G	SKCM	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1111
p.S101F	TCGA-DU-6392	LGG	TCGA	SVDSKVPSL	DEG_COP1_1	94:102	Mutation altering degron motif	0.7982
p.S101F	DO22237	LGG	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation altering degron motif	0.7982
p.G92R	TCGA-EJ-A8FP	PRAD	TCGA	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.2778
p.G92R	DO51331	PRAD	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.2778
p.S85F	TCGA-FW-A3R5	SKCM	TCGA	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.0833
p.S85F	DO37406	SKCM	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.0833
p.S291C	TCGA-MV-A51V	BLCA	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.643
p.S294F	TCGA-WE-A8ZT	SKCM	TCGA	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.6871
p.S101P	DO227844	COCA	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation altering degron motif	0.6752
p.R282C	DO233652	GACA	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation substituting flanking lysine	0.25
p.A84S	DO229015	LICA	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.0556
p.D107Y	DO229006	LICA	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.1944
p.D294Y	DO23556	LUAD	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.7325
p.H111N	DO230974	LUSC	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.0833
p.H111N	DO224632	LUSC	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.0833
p.R282H	DO27849	MALY	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation substituting flanking lysine	0.25
p.E109K	DO222550	MELA	ICGC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.1389
p.A285V	DO38380	STAD	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.2222
p.R301Q	DO47925	STAD	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.2222
p.R301W	DO43122	UCEC	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.2222
p.D294N	DO41903	UCEC	ICGC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.6932
p.F86L	SIDM00113	Kidney Carcinoma	GDSC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.1111
p.F86L	ACH-001208	Kidney Cancer	CCLE	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.1111
p.F86L	TK10	kidney	COSMIC	SVDSKVPSL	DEG_COP1_1	94:102	Mutation rewiring degron network	0.1111
p.S287F	SIDM00277	Acute Myeloid Leukemia	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.2778
p.S287F	ACH-000198	Leukemia	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.2778
p.S287F	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.2778
p.A280T	SIDM00690	Head and Neck Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0833
p.A280T	SIDM00596	Endometrial Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0833
p.P286A	SIDM00929	Chondrosarcoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.25
p.P286A	SIDM00118	Colorectal Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.25
p.K292N	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.5806
p.K292N	ACH-000900	Lung Cancer	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.5806
p.K292N	NCI-H23	lung	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.5806
p.V281I	SIDM00954	Breast Carcinoma	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1111
p.V281I	COLO-824	breast	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1111
p.R298C	SIDM00951	T-Lymphoblastic Leukemia	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.R298C	CTV-1	haematopoietic and lymphoid tissue	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.T279I	SIDM01424	B-Lymphoblastic Leukemia	GDSC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.0556
p.L283V	ACH-000323	Brain Cancer	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.L283V	42-MG-BA	central nervous system	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.R282P	ACH-000843	Lung Cancer	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation substituting flanking lysine	0.25
p.R282P	HARA	lung	COSMIC	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation substituting flanking lysine	0.25
p.D284N	ACH-000990	Endometrial/Uterine Cancer	CCLE	NRSKLSNVA	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA18

UniProt ID: Q8TC71

Entrez ID: 132671

Protein name: Mitochondria-eating protein (Spermatogenesis-associated protein 18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA18 in