DegronMD

Uniprot ID: Q8TC71

Source protein: Mitochondria-eating protein

Source gene: SPATA18

Class: DEG_COP1_1

Location: 94:102

E3 ligase: COP1

DEGRON score: 0.9434

ASA_SCORE: 71.8444

COIL: 0.7277

CONS_SCORE: 0.6746

DSS_SCORE: 0.4856

HELIX: 0.236

FCONS_SCORE: 1.0336

RIG_SCORE: 0.6744

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D107N	TCGA-99-8025	LUAD	TCGA	SVDSKVPSL	DEG_COP1_1	0.1944
p.D107N	DO24255	LUAD	ICGC	SVDSKVPSL	DEG_COP1_1	0.1944
p.S101F	TCGA-DU-6392	LGG	TCGA	SVDSKVPSL	DEG_COP1_1	0.7982
p.S101F	DO22237	LGG	ICGC	SVDSKVPSL	DEG_COP1_1	0.7982
p.G92R	TCGA-EJ-A8FP	PRAD	TCGA	SVDSKVPSL	DEG_COP1_1	0.2778
p.G92R	DO51331	PRAD	ICGC	SVDSKVPSL	DEG_COP1_1	0.2778
p.S85F	TCGA-FW-A3R5	SKCM	TCGA	SVDSKVPSL	DEG_COP1_1	0.0833
p.S85F	DO37406	SKCM	ICGC	SVDSKVPSL	DEG_COP1_1	0.0833
p.S101P	DO227844	COCA	ICGC	SVDSKVPSL	DEG_COP1_1	0.6752
p.A84S	DO229015	LICA	ICGC	SVDSKVPSL	DEG_COP1_1	0.0556
p.D107Y	DO229006	LICA	ICGC	SVDSKVPSL	DEG_COP1_1	0.1944
p.H111N	DO230974	LUSC	ICGC	SVDSKVPSL	DEG_COP1_1	0.0833
p.H111N	DO224632	LUSC	ICGC	SVDSKVPSL	DEG_COP1_1	0.0833
p.E109K	DO222550	MELA	ICGC	SVDSKVPSL	DEG_COP1_1	0.1389
p.F86L	SIDM00113	Kidney Carcinoma	GDSC	SVDSKVPSL	DEG_COP1_1	0.1111
p.F86L	ACH-001208	Kidney Cancer	CCLE	SVDSKVPSL	DEG_COP1_1	0.1111
p.F86L	TK10	kidney	COSMIC	SVDSKVPSL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TC71	Mitochondria-eating protein	DEG_COP1_1	94:102	SVDSKVPSL	COP1	0.9434	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons