DegronMD

Uniprot ID: O60343

Source protein: TBC1 domain family member 4

Source gene: TBC1D4

Class: DEG_APCC_DBOX_1

Location: 354:362

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5074

ASA_SCORE: 38.9333

COIL: 0.213

CONS_SCORE: 0.4392

DSS_SCORE: 0.4222

HELIX: 0.0357

FCONS_SCORE: 1.081

RIG_SCORE: 0.7869

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L358F	TCGA-A5-A0G1	UCEC	TCGA	NRTMLFQVG	DEG_APCC_DBOX_1	0.6981
p.L358F	DO42472	UCEC	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.6981
p.L358V	TCGA-AG-3592	READ	TCGA	NRTMLFQVG	DEG_APCC_DBOX_1	0.6765
p.L358V	DO37308	READ	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.6765
p.R363Q	TCGA-B5-A0JY	UCEC	TCGA	NRTMLFQVG	DEG_APCC_DBOX_1	0.3056
p.R363Q	DO43041	UCEC	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.3056
p.R363Q	SIDM01611	Endometrial Carcinoma	GDSC	NRTMLFQVG	DEG_APCC_DBOX_1	0.3056
p.R363Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	NRTMLFQVG	DEG_APCC_DBOX_1	0.3056
p.G362W	TCGA-DA-A1I1	SKCM	TCGA	NRTMLFQVG	DEG_APCC_DBOX_1	0.6714
p.E361K	DO5507	BRCA	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.7022
p.Q347E	DO233267	GACA	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.1389
p.E367D	DO52066	HNSC	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.1944
p.N367K	DO228948	LICA	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.1944
p.D359Y	DO218922	LUAD	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.7325
p.D359N	DO222683	MELA	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.6932
p.D359N	DO37417	SKCM	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.6932
p.C357S	DO34136	PACA	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.7541
p.V345A	DO47903	STAD	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.0833
p.K365E	DO43154	UCEC	ICGC	NRTMLFQVG	DEG_APCC_DBOX_1	0.25
p.H345P	SIDM00060	Ovarian Carcinoma	GDSC	NRTMLFQVG	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_APCC_DBOX_1	354:362	NRTMLFQVG	APC,CDC20,FZR1	0.5074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons