DegronMD

Uniprot ID: Q3KR37

Source protein: Protein Aster-B

Source gene: GRAMD1B

Class: DEG_APCC_DBOX_1

Location: 482:490

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6202

ASA_SCORE: 33.4111

COIL: 0.1948

CONS_SCORE: 0.4003

DSS_SCORE: 0.1212

HELIX: 0.0052

FCONS_SCORE: 0.7941

RIG_SCORE: 0.9189

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S494I	TCGA-37-A5EM	LUSC	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	0.2222
p.V472M	TCGA-A5-A0G2	UCEC	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	0.0556
p.V472M	TCGA-AX-A2HD	UCEC	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	0.0556
p.R491Q	TCGA-G4-6320	COAD	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	0.3056
p.R488H	TCGA-IB-7651	PAAD	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	0.7133
p.R488H	TCGA-VQ-A8PF	STAD	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	0.7133
p.R498Q	DO8159	COAD	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1111
p.E473K	DO222765	COCA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.0833
p.E473K	SIDM00193	Colorectal Carcinoma	GDSC	NRYTLTRVA	DEG_APCC_DBOX_1	0.0833
p.E473K	SNU-81	large_intestine	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.0833
p.H477N	DO233158	GACA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1944
p.K500T	DO233191	GACA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.0556
p.V474F	DO229038	LICA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1111
p.L475F	DO220907	MELA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1389
p.R490C	DO222868	MELA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.8301
p.R490C	DO229459	SKCA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.8301
p.R495H	DO46657	PAAD	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1944
p.R495H	DO222348	STAD	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1944
p.V479M	DO42608	UCEC	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.25
p.V479M	DO41235	UCEC	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.25
p.E473D	DO41331	UCEC	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	0.0833
p.G474A	NCI-H835	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1111
p.D486A	ChaGo-K-1	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.7793
p.L495P	639-V	urinary_tract	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1944
p.D490A	ChaGo-K-1	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.7793
p.C489R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.8301
p.V476L	VMRC-LCD	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1667
p.E495K	SNU-81	large_intestine	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1944
p.V472L	VMRC-LCD	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.0556
p.L499P	639-V	urinary_tract	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.0833
p.L495R	SNU-1040	large_intestine	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRYTLTRVA

Degron related mutations and impact score

Drug responses associated with GRAMD1B mutations

All proteins holding degron of NRYTLTRVA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KR37	Protein Aster-B	DEG_APCC_DBOX_1	482:490	NRYTLTRVA	APC,CDC20,FZR1	0.6202	More...