DegronMD - Q3KR37(GRAMD1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S494I	TCGA-37-A5EM	LUSC	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.2222
p.V472M	TCGA-A5-A0G2	UCEC	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0556
p.V472M	TCGA-AX-A2HD	UCEC	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0556
p.R572Q	TCGA-A5-A0G2	UCEC	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0556
p.R572Q	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0556
p.D588G	TCGA-B5-A11E	UCEC	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.6087
p.T585M	TCGA-BR-8078	STAD	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.8534
p.S581N	TCGA-BR-8487	STAD	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation blocking phosphorylation signal	0.75
p.H575N	TCGA-CR-7385	HNSC	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1389
p.R594M	TCGA-DF-A2KN	UCEC	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1944
p.R491Q	TCGA-G4-6320	COAD	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.3056
p.R488H	TCGA-IB-7651	PAAD	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.7133
p.R488H	TCGA-VQ-A8PF	STAD	TCGA	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.7133
p.R498Q	DO8159	COAD	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1111
p.R573C	DO222492	COCA	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.R573C	DO41199	UCEC	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.E473K	DO222765	COCA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0833
p.E473K	SIDM00193	Colorectal Carcinoma	GDSC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0833
p.E473K	SNU-81	large intestine	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0833
p.H477N	DO233158	GACA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944
p.K500T	DO233191	GACA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0556
p.H582N	DO14282	HNSC	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.7423
p.D597Y	DO229036	LICA	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1111
p.V474F	DO229038	LICA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1111
p.A576G	DO218944	LUAD	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1667
p.L475F	DO220907	MELA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1389
p.R490C	DO222868	MELA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.8301
p.R490C	DO229459	SKCA	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.8301
p.G599C	DO50672	ORCA	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0556
p.R495H	DO46657	PAAD	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944
p.R495H	DO222348	STAD	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944
p.R573H	DO36531	READ	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.S588N	DO47867	STAD	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.7069
p.T592M	DO38288	STAD	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.25
p.T592M	SIDM02049	Pancreatic Carcinoma	GDSC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.25
p.D595G	DO41644	UCEC	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1667
p.V479M	DO42608	UCEC	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.25
p.V479M	DO41235	UCEC	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.25
p.R579Q	DO41235	UCEC	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.25
p.R579Q	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.25
p.R579Q	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.25
p.E473D	DO41331	UCEC	ICGC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0833
p.G599S	SIDM01146	Gastric Carcinoma	GDSC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0556
p.G599S	NCI-SNU-1	stomach	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0556
p.V598E	SIDM00192	Colorectal Carcinoma	GDSC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.D590E	ACH-000512	Myeloma	CCLE	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.3056
p.G592S	ACH-000932	Gastric Cancer	CCLE	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.25
p.G592S	NCI-SNU-1	stomach	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.25
p.G474A	NCI-H835	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1111
p.D486A	ChaGo-K-1	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.7793
p.G574R	JHOS-4	ovary	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.1111
p.L495P	639-V	urinary tract	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944
p.G578R	JHOS-4	ovary	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.2222
p.D490A	ChaGo-K-1	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.7793
p.C489R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.8301
p.V476L	VMRC-LCD	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1667
p.T589A	KYSE-510	oesophagus	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation altering degron motif	0.7139
p.E495K	SNU-81	large intestine	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944
p.V472L	VMRC-LCD	lung	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0556
p.Y573C	C2BBe1	large intestine	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	582:589	Mutation rewiring degron network	0.0833
p.L499P	639-V	urinary tract	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.0833
p.L495R	SNU-1040	large intestine	COSMIC	NRYTLTRVA	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.1944

Kaplan plot for GRAMD1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRAMD1B

UniProt ID: Q3KR37

Entrez ID: 57476

Protein name: Protein Aster-B (GRAM domain-containing protein 1B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRAMD1B in