DegronMD

Uniprot ID: Q3KR37

Source protein: Protein Aster-B

Source gene: GRAMD1B

Class: DEG_SCF_FBW7_2

Location: 582:589

E3 ligase: FBXW7

DEGRON score: 0.6425

ASA_SCORE: 89.7125

COIL: 0.876

CONS_SCORE: 0.2551

DSS_SCORE: 0.6182

HELIX: 0.0781

FCONS_SCORE: 1.03

RIG_SCORE: 0.662

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R572Q	TCGA-A5-A0G2	UCEC	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	0.0556
p.R572Q	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	0.0556
p.D588G	TCGA-B5-A11E	UCEC	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	0.6087
p.T585M	TCGA-BR-8078	STAD	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	0.8534
p.S581N	TCGA-BR-8487	STAD	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	0.75
p.H575N	TCGA-CR-7385	HNSC	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	0.1389
p.R594M	TCGA-DF-A2KN	UCEC	TCGA	PVTTPTDE	DEG_SCF_FBW7_2	0.1944
p.R573C	DO222492	COCA	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.0833
p.R573C	DO41199	UCEC	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.0833
p.H582N	DO14282	HNSC	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.7423
p.D597Y	DO229036	LICA	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.1111
p.A576G	DO218944	LUAD	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.1667
p.G599C	DO50672	ORCA	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.0556
p.R573H	DO36531	READ	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.0833
p.S588N	DO47867	STAD	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.7069
p.T592M	DO38288	STAD	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.25
p.T592M	SIDM02049	Pancreatic Carcinoma	GDSC	PVTTPTDE	DEG_SCF_FBW7_2	0.25
p.D595G	DO41644	UCEC	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.1667
p.R579Q	DO41235	UCEC	ICGC	PVTTPTDE	DEG_SCF_FBW7_2	0.25
p.R579Q	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVTTPTDE	DEG_SCF_FBW7_2	0.25
p.R579Q	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	0.25
p.G599S	SIDM01146	Gastric Carcinoma	GDSC	PVTTPTDE	DEG_SCF_FBW7_2	0.0556
p.G599S	NCI-SNU-1	stomach	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	0.0556
p.V598E	SIDM00192	Colorectal Carcinoma	GDSC	PVTTPTDE	DEG_SCF_FBW7_2	0.0833
p.D590E	ACH-000512	Myeloma	CCLE	PVTTPTDE	DEG_SCF_FBW7_2	0.3056
p.G592S	ACH-000932	Gastric Cancer	CCLE	PVTTPTDE	DEG_SCF_FBW7_2	0.25
p.G592S	NCI-SNU-1	stomach	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	0.25
p.G574R	JHOS-4	ovary	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	0.1111
p.G578R	JHOS-4	ovary	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	0.2222
p.T589A	KYSE-510	oesophagus	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	0.7139
p.Y573C	C2BBe1	large_intestine	COSMIC	PVTTPTDE	DEG_SCF_FBW7_2	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTPTDE

Degron related mutations and impact score

Drug responses associated with GRAMD1B mutations

All proteins holding degron of PVTTPTDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3KR37	Protein Aster-B	DEG_SCF_FBW7_2	582:589	PVTTPTDE	FBXW7	0.6425	More...