DegronMD

Uniprot ID: O76083

Source protein: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Source gene: PDE9A

Class: DEG_SCF_SKP2-CKS1_1

Location: 70:77

E3 ligase: SKP2,CSK1

DEGRON score: 0.9736

ASA_SCORE: 87.9

COIL: 0.795

CONS_SCORE: 0.3814

DSS_SCORE: 0.5364

HELIX: 0.0296

FCONS_SCORE: 0.9215

RIG_SCORE: 0.724

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R73C	TCGA-A5-A0G2	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.719
p.R73C	TCGA-AJ-A3OJ	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.719
p.R73C	TCGA-EO-A22S	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.719
p.P75Q	TCGA-AX-A2HC	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.7035
p.A69T	TCGA-AX-A2HD	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A69T	TCGA-CC-A7IJ	LIHC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A69T	TCGA-DF-A2KZ	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A69T	TCGA-EA-A410	CESC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P75L	TCGA-D5-6927	COAD	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.7582
p.K84N	TCGA-IB-7651	PAAD	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.25
p.E77D	DO224768	BRCA	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.6758
p.R85H	DO9876	COAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R85H	NCI-H1155	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R83C	DO234257	ESAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R83C	DO37444	SKCM	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R83H	DO234308	ESAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A65S	DO229029	LICA	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E65D	DO45433	LUSC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E65K	DO45433	LUSC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1944
p.F87I	DO220886	MELA	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.5
p.A61S	DO46657	PAAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.0833
p.V64G	DO47813	STAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A76S	DO38312	STAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.7588
p.V75F	DO43186	UCEC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.7068
p.V86G	DO41608	UCEC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L63I	DO41572	UCEC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.1389
p.G72C	NCI-H838	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.76
p.E74K	A2058	skin	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.7022
p.R86H	NCI-H1155	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P68L	IM-95	stomach	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P68L	TE-15	oesophagus	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R60H	NCI-H1155	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.0556
p.N70D	SU-DHL-8	NS	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.5821
p.S71N	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.5958
p.I78T	CAL-72	bone	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.3056
p.G87C	NCI-H838	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NSERTPYK

Degron related mutations and impact score

Drug responses associated with PDE9A mutations

All proteins holding degron of NSERTPYK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76083	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	DEG_SCF_SKP2-CKS1_1	70:77	NSERTPYK	SKP2,CSK1	0.9736	More...