DegronMD - O76083(PDE9A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R73C	TCGA-A5-A0G2	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.719
p.R73C	TCGA-AJ-A3OJ	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.719
p.R73C	TCGA-EO-A22S	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.719
p.K506N	TCGA-AA-3864	COAD	TCGA	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation substituting flanking lysine	0.3611
p.P75Q	TCGA-AX-A2HC	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.7035
p.A69T	TCGA-AX-A2HD	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.3056
p.A69T	TCGA-CC-A7IJ	LIHC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.3056
p.A69T	TCGA-DF-A2KZ	UCEC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.3056
p.A69T	TCGA-EA-A410	CESC	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.3056
p.P75L	TCGA-D5-6927	COAD	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.7582
p.K84N	TCGA-IB-7651	PAAD	TCGA	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation substituting flanking lysine	0.25
p.A510V	TCGA-XK-AAIW	PRAD	TCGA	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.1389
p.D489N	TCGA-ZH-A8Y5	CHOL	TCGA	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.0833
p.E77D	DO224768	BRCA	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.6758
p.R85H	DO9876	COAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1111
p.R85H	NCI-H1155	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1111
p.R83C	DO234257	ESAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1667
p.R83C	DO37444	SKCM	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1667
p.R83H	DO234308	ESAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1667
p.D489G	DO14343	HNSC	ICGC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.0833
p.A65S	DO229029	LICA	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1944
p.E65D	DO45433	LUSC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1944
p.E65K	DO45433	LUSC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1944
p.F87I	DO220886	MELA	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation blocking phosphorylation signal	0.5
p.A61S	DO46657	PAAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.0833
p.V64G	DO47813	STAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1667
p.A76S	DO38312	STAD	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.7588
p.V75F	DO43186	UCEC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.7068
p.V86G	DO41608	UCEC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.0833
p.L63I	DO41572	UCEC	ICGC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.1389
p.A512S	SIDM00491	Thyroid Gland Carcinoma	GDSC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.0833
p.A512S	ASH-3	thyroid	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.0833
p.R495Q	BHY	upper aerodigestive tract	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.25
p.R495Q	TC-YIK	cervix	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.25
p.G72C	NCI-H838	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.76
p.S492F	SK-MEL-31	skin	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation substituting flanking lysine	0.2778
p.S511F	SK-MEL-31	skin	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation blocking phosphorylation signal	0.5556
p.R502Q	BHY	upper aerodigestive tract	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation altering degron motif	0.7329
p.R502Q	TC-YIK	cervix	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation altering degron motif	0.7329
p.E74K	A2058	skin	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.7022
p.R488Q	BHY	upper aerodigestive tract	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.0556
p.R488Q	TC-YIK	cervix	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation rewiring degron network	0.0556
p.R86H	NCI-H1155	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.0833
p.P68L	IM-95	stomach	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.2778
p.P68L	TE-15	oesophagus	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.2778
p.L499R	JVM-2	haematopoietic and lymphoid tissue	COSMIC	VAPFMD	LIG_APCC_ABBA_1	498:503	Mutation altering degron motif	0.8428
p.R60H	NCI-H1155	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.0556
p.N70D	SU-DHL-8	NS	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.5821
p.S71N	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation altering degron motif	0.5958
p.I78T	CAL-72	bone	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation rewiring degron network	0.3056
p.G87C	NCI-H838	lung	COSMIC	NSERTPYK	DEG_SCF_SKP2-CKS1_1	70:77	Mutation blocking phosphorylation signal	0.5

Kaplan plot for PDE9A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE9A

UniProt ID: O76083

Entrez ID: 5152

Protein name: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE9A in