DegronMD

Uniprot ID: O76083

Source protein: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Source gene: PDE9A

Class: LIG_APCC_ABBA_1

Location: 498:503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6808

ASA_SCORE: 42.5833

COIL: 0.8502

CONS_SCORE: 0.7643

DSS_SCORE: 0.3549

HELIX: 0.0987

FCONS_SCORE: 1.1015

RIG_SCORE: 0.8013

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L499R	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.8428
p.R502Q	BHY	upper_aerodigestive_tract	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.7329
p.R502Q	TC-YIK	cervix	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.7329
p.S511F	SK-MEL-31	skin	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.5556
p.K506N	TCGA-AA-3864	COAD	TCGA	VAPFMD	LIG_APCC_ABBA_1	0.3611
p.S492F	SK-MEL-31	skin	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.2778
p.R495Q	BHY	upper_aerodigestive_tract	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.25
p.R495Q	TC-YIK	cervix	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.25
p.A510V	TCGA-XK-AAIW	PRAD	TCGA	VAPFMD	LIG_APCC_ABBA_1	0.1389
p.D489N	TCGA-ZH-A8Y5	CHOL	TCGA	VAPFMD	LIG_APCC_ABBA_1	0.0833
p.D489G	DO14343	HNSC	ICGC	VAPFMD	LIG_APCC_ABBA_1	0.0833
p.A512S	SIDM00491	Thyroid Gland Carcinoma	GDSC	VAPFMD	LIG_APCC_ABBA_1	0.0833
p.A512S	ASH-3	thyroid	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.0833
p.R488Q	BHY	upper_aerodigestive_tract	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.0556
p.R488Q	TC-YIK	cervix	COSMIC	VAPFMD	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76083	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	LIG_APCC_ABBA_1	498:503	VAPFMD	APC,CDC20,FZR1	0.6808	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons