DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NSESGE
Uniprot ID:
O15446
Source protein:
DNA-directed RNA polymerase I subunit RPA34
Source gene:
POLR1G
Class:
DEG_Kelch_Keap1_1
Location:
487:492
E3 ligase:
KEAP1
DEGRON score:
0.9912
ASA_SCORE:
104.7667
COIL:
0.9492
CONS_SCORE:
0.3288
DSS_SCORE:
0.9165
HELIX:
0.036
FCONS_SCORE:
1.0058
RIG_SCORE:
0.5024
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POLR1G mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSESGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15446
DNA-directed RNA polymerase I subunit RPA34
DEG_Kelch_Keap1_1
487:492
NSESGE
KEAP1
0.9912
More...
P67809
Y-box-binding protein 1
DEG_Kelch_Keap1_1
164:169
NSESGE
KEAP1
0.8975
More...