DegronMD

Uniprot ID: P67809

Source protein: Y-box-binding protein 1

Source gene: YBX1

Class: DEG_Kelch_Keap1_1

Location: 164:169

E3 ligase: KEAP1

DEGRON score: 0.8975

ASA_SCORE: 76.8333

COIL: 0.8443

CONS_SCORE: 0.281

DSS_SCORE: 0.7592

HELIX: 0.0768

FCONS_SCORE: 0.9548

RIG_SCORE: 0.5336

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R156H	TCGA-B5-A11E	UCEC	TCGA	NSESGE	DEG_Kelch_Keap1_1	0.1111
p.R156H	DO41644	UCEC	ICGC	NSESGE	DEG_Kelch_Keap1_1	0.1111
p.R156H	SIDM00217	Colorectal Carcinoma	GDSC	NSESGE	DEG_Kelch_Keap1_1	0.1111
p.R156H	ACH-000999	Colon/Colorectal Cancer	CCLE	NSESGE	DEG_Kelch_Keap1_1	0.1111
p.R156H	SNU-1040	large_intestine	COSMIC	NSESGE	DEG_Kelch_Keap1_1	0.1111
p.G168E	DO50970	LICA	ICGC	NSESGE	DEG_Kelch_Keap1_1	0.7199
p.P178T	DO229275	THCA	ICGC	NSESGE	DEG_Kelch_Keap1_1	0.0833
p.Q159L	DO229224	THCA	ICGC	NSESGE	DEG_Kelch_Keap1_1	0.1944
p.Q159L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	NSESGE	DEG_Kelch_Keap1_1	0.1944
p.E169A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	NSESGE	DEG_Kelch_Keap1_1	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15446	DNA-directed RNA polymerase I subunit RPA34	DEG_Kelch_Keap1_1	487:492	NSESGE	KEAP1	0.9912	More...
P67809	Y-box-binding protein 1	DEG_Kelch_Keap1_1	164:169	NSESGE	KEAP1	0.8975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons