DegronMD

Degron: NSSYSLGP

Uniprot ID: Q96BU1

Source protein: S100P-binding protein

Source gene: S100PBP

Class: CBL_PTK

Location: 99:106

E3 ligase: CBL

DEGRON score: 0.9974

ASA_SCORE: 72.4625

COIL: 0.8448

CONS_SCORE: 0.7457

DSS_SCORE: 0.5882

HELIX: 0.0578

FCONS_SCORE: 1.0711

RIG_SCORE: 0.6626

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N99K	TCGA-CA-6717	COAD	TCGA	NSSYSLGP	CBL_PTK	0.6918
p.N99K	DO8264	COAD	ICGC	NSSYSLGP	CBL_PTK	0.6918
p.S101A	TCGA-AA-3977	COAD	TCGA	NSSYSLGP	CBL_PTK	0.6477
p.S101A	DO8730	COAD	ICGC	NSSYSLGP	CBL_PTK	0.6477
p.T94S	DO23262	LINC	ICGC	NSSYSLGP	CBL_PTK	0.6389
p.G105E	DO228829	MALY	ICGC	NSSYSLGP	CBL_PTK	0.6087
p.G105E	SIDM00694	Other Solid Cancers	GDSC	NSSYSLGP	CBL_PTK	0.6087
p.G105E	SIDM00785	Acute Myeloid Leukemia	GDSC	NSSYSLGP	CBL_PTK	0.6087
p.R96L	TCGA-L9-A5IP	LUAD	TCGA	NSSYSLGP	CBL_PTK	0.25
p.R96L	DO49873	LUAD	ICGC	NSSYSLGP	CBL_PTK	0.25
p.R96Q	SIDM00673	Breast Carcinoma	GDSC	NSSYSLGP	CBL_PTK	0.25
p.P111H	TCGA-CG-5723	STAD	TCGA	NSSYSLGP	CBL_PTK	0.1944
p.P111H	DO38376	STAD	ICGC	NSSYSLGP	CBL_PTK	0.1944
p.L113F	DO222708	MELA	ICGC	NSSYSLGP	CBL_PTK	0.1389

Showing 1 to 14 of 14 entries

Drug responses associated with S100PBP mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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All proteins holding degron of NSSYSLGP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BU1	S100P-binding protein	CBL_PTK	99:106	NSSYSLGP	CBL	0.9974	More...

Showing 1 to 1 of 1 entries