DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
NSSYSLGP
Uniprot ID:
Q96BU1
Source protein:
S100P-binding protein
Source gene:
S100PBP
Class:
CBL_PTK
Location:
99:106
E3 ligase:
CBL
DEGRON score:
0.9974
ASA_SCORE:
72.4625
COIL:
0.8448
CONS_SCORE:
0.7457
DSS_SCORE:
0.5882
HELIX:
0.0578
FCONS_SCORE:
1.0711
RIG_SCORE:
0.6626
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S101A
TCGA-AA-3977
COAD
TCGA
NSSYSLGP
CBL_PTK
0.6477
p.S101A
DO8730
COAD
ICGC
NSSYSLGP
CBL_PTK
0.6477
p.N99K
TCGA-CA-6717
COAD
TCGA
NSSYSLGP
CBL_PTK
0.6918
p.N99K
DO8264
COAD
ICGC
NSSYSLGP
CBL_PTK
0.6918
p.P111H
TCGA-CG-5723
STAD
TCGA
NSSYSLGP
CBL_PTK
0.1944
p.P111H
DO38376
STAD
ICGC
NSSYSLGP
CBL_PTK
0.1944
p.R96L
TCGA-L9-A5IP
LUAD
TCGA
NSSYSLGP
CBL_PTK
0.25
p.R96L
DO49873
LUAD
ICGC
NSSYSLGP
CBL_PTK
0.25
p.T94S
DO23262
LINC
ICGC
NSSYSLGP
CBL_PTK
0.6389
p.G105E
DO228829
MALY
ICGC
NSSYSLGP
CBL_PTK
0.6087
p.G105E
SIDM00694
Other Solid Cancers
GDSC
NSSYSLGP
CBL_PTK
0.6087
p.G105E
SIDM00785
Acute Myeloid Leukemia
GDSC
NSSYSLGP
CBL_PTK
0.6087
p.L113F
DO222708
MELA
ICGC
NSSYSLGP
CBL_PTK
0.1389
p.R96Q
SIDM00673
Breast Carcinoma
GDSC
NSSYSLGP
CBL_PTK
0.25
Drug responses associated with S100PBP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSSYSLGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96BU1
S100P-binding protein
CBL_PTK
99:106
NSSYSLGP
CBL
0.9974
More...
