DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NTLHTYTLSP
Uniprot ID:
Q9NPG4
Source protein:
Protocadherin-12
Source gene:
PCDH12
Class:
CBL_PTK
Location:
167:176
E3 ligase:
CBL
DEGRON score:
0.7587
ASA_SCORE:
55.93
COIL:
0.5501
CONS_SCORE:
0.6539
DSS_SCORE:
0.4729
HELIX:
0.0363
FCONS_SCORE:
0.9918
RIG_SCORE:
0.7224
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S175Y
TCGA-AG-A002
READ
TCGA
NTLHTYTLSP
CBL_PTK
0.6009
p.A181V
TCGA-WS-AB45
COAD
TCGA
NTLHTYTLSP
CBL_PTK
0.1944
p.A181V
DO51734
COAD
ICGC
NTLHTYTLSP
CBL_PTK
0.1944
p.D163Y
DO50331
ESAD
ICGC
NTLHTYTLSP
CBL_PTK
0.2222
p.D163E
DO228952
LICA
ICGC
NTLHTYTLSP
CBL_PTK
0.2222
p.N167K
DO229034
LICA
ICGC
NTLHTYTLSP
CBL_PTK
0.6918
p.T168N
DO229008
LICA
ICGC
NTLHTYTLSP
CBL_PTK
0.5944
p.T168I
SIDM00579
Neuroblastoma
GDSC
NTLHTYTLSP
CBL_PTK
0.5966
p.T168I
ACH-002277
Neuroblastoma
CCLE
NTLHTYTLSP
CBL_PTK
0.5966
p.T168I
NB(TU)1-10
autonomic_ganglia
COSMIC
NTLHTYTLSP
CBL_PTK
0.5966
Drug responses associated with PCDH12 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NTLHTYTLSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NPG4
Protocadherin-12
CBL_PTK
167:176
NTLHTYTLSP
CBL
0.7587
More...
