DegronMD

Uniprot ID: Q8IY42

Source protein: Uncharacterized protein C4orf19

Source gene: C4orf19

Class: DEG_SCF_FBW7_1

Location: 103:110

E3 ligase: FBXW7

DEGRON score: 0.9501

ASA_SCORE: 70.675

COIL: 0.8479

CONS_SCORE: 0.5001

DSS_SCORE: 0.7251

HELIX: 0.0524

FCONS_SCORE: 1.048

RIG_SCORE: 0.596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N99S	TCGA-CA-6717	COAD	TCGA	PAATPQPT	DEG_SCF_FBW7_1	0.2222
p.N99S	DO8264	COAD	ICGC	PAATPQPT	DEG_SCF_FBW7_1	0.2222
p.H94R	TCGA-DD-AAEA	LIHC	TCGA	PAATPQPT	DEG_SCF_FBW7_1	0.0833
p.H94R	DO52266	LIHC	ICGC	PAATPQPT	DEG_SCF_FBW7_1	0.0833
p.Q108H	TCGA-DX-A6YV	SARC	TCGA	PAATPQPT	DEG_SCF_FBW7_1	0.647
p.Q108H	DO220011	SARC	ICGC	PAATPQPT	DEG_SCF_FBW7_1	0.647
p.Q117H	DO229019	LICA	ICGC	PAATPQPT	DEG_SCF_FBW7_1	0.1389
p.G97S	SIDM00210	Ovarian Carcinoma	GDSC	PAATPQPT	DEG_SCF_FBW7_1	0.1667
p.G97S	SIDM00094	Kidney Carcinoma	GDSC	PAATPQPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IY42	Uncharacterized protein C4orf19	DEG_SCF_FBW7_1	103:110	PAATPQPT	FBXW7	0.9501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons