DegronMD

Uniprot ID: Q06455

Source protein: Protein CBFA2T1

Source gene: RUNX1T1

Class: DEG_SCF_FBW7_1

Location: 584:591

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 98.8125

COIL: 0.963

CONS_SCORE: 0.54

DSS_SCORE: 0.8499

HELIX: 0.0148

FCONS_SCORE: 1.1601

RIG_SCORE: 0.5703

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P599L	TCGA-A5-AB3J	UCEC	TCGA	PAATPRST	DEG_SCF_FBW7_1	0.1111
p.P599L	TCGA-AC-A8OP	BRCA	TCGA	PAATPRST	DEG_SCF_FBW7_1	0.1111
p.T582M	TCGA-AJ-A2QK	UCEC	TCGA	PAATPRST	DEG_SCF_FBW7_1	0.2778
p.T598S	TCGA-CN-A63T	HNSC	TCGA	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.P595Q	TCGA-O2-A52S	LUSC	TCGA	PAATPRST	DEG_SCF_FBW7_1	0.6667
p.P575T	TCGA-T3-A92N	HNSC	TCGA	PAATPRST	DEG_SCF_FBW7_1	0.0833
p.S580F	TCGA-W3-A825	SKCM	TCGA	PAATPRST	DEG_SCF_FBW7_1	0.2222
p.R577H	DO230347	COCA	ICGC	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.R577H	DO228138	PBCA	ICGC	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.R577H	DO232761	PBCA	ICGC	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.R577C	DO234461	ESAD	ICGC	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.R577C	DO22237	LGG	ICGC	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.R577S	DO45492	LUSC	ICGC	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.P576L	DO220906	MELA	ICGC	PAATPRST	DEG_SCF_FBW7_1	0.1111
p.P576L	DO42713	UCEC	ICGC	PAATPRST	DEG_SCF_FBW7_1	0.1111
p.S574I	ACH-000438	Lung Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.0556
p.S574I	LU-65	lung	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.0556
p.P593Q	ACH-000672	Lung Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.2778
p.T601P	ACH-000842	Colon/Colorectal Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.0556
p.M580I	ACH-000881	Skin Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.2222
p.M580I	MEL-JUSO	skin	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.2222
p.S574R	ACH-000951	Lung Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.0556
p.S574R	NCI-H2342	lung	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.0556
p.P579Q	ACH-000955	Colon/Colorectal Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.1944
p.P579Q	SNU-407	large_intestine	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.1944
p.S574N	ACH-000985	Colon/Colorectal Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.0556
p.T591A	ACH-000995	Leukemia	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.825
p.P583Q	ACH-000998	Colon/Colorectal Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.3056
p.G577R	ACH-001136	Lung Cancer	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.G577R	NCI-H187	lung	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.1389
p.E600G	ACH-001991	Primary	CCLE	PAATPRST	DEG_SCF_FBW7_1	0.0833
p.S585R	NCI-H2342	lung	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.7427
p.M591I	MEL-JUSO	skin	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.7618
p.S578R	NCI-H1623	lung	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.1667
p.G588R	NCI-H187	lung	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.7568
p.P590Q	SNU-407	large_intestine	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.7035
p.S585I	LU-65	lung	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.7341
p.E583K	Sarc9371	bone	COSMIC	PAATPRST	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAATPRST

Degron related mutations and impact score

Drug responses associated with RUNX1T1 mutations

All proteins holding degron of PAATPRST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q06455	Protein CBFA2T1	DEG_SCF_FBW7_1	584:591	PAATPRST	FBXW7	0.9982	More...