DegronMD

Uniprot ID: Q9HBG7

Source protein: T-lymphocyte surface antigen Ly-9

Source gene: LY9

Class: DEG_SCF_FBW7_1

Location: 495:502

E3 ligase: FBXW7

DEGRON score: 0.913

ASA_SCORE: 87.8125

COIL: 0.9498

CONS_SCORE: 0.4133

DSS_SCORE: 0.4633

HELIX: 0.0266

FCONS_SCORE: 0.9658

RIG_SCORE: 0.6376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P485S	TCGA-BF-A5EQ	SKCM	TCGA	PADTPEPT	DEG_SCF_FBW7_1	0.0556
p.P485S	DO222875	MELA	ICGC	PADTPEPT	DEG_SCF_FBW7_1	0.0556
p.P485S	DO219452	SKCM	ICGC	PADTPEPT	DEG_SCF_FBW7_1	0.0556
p.S512Y	TCGA-DU-7298	LGG	TCGA	PADTPEPT	DEG_SCF_FBW7_1	0.5
p.S512Y	DO22679	LGG	ICGC	PADTPEPT	DEG_SCF_FBW7_1	0.5
p.E493K	TCGA-ZF-AA4V	BLCA	TCGA	PADTPEPT	DEG_SCF_FBW7_1	0.2778
p.E493K	DO219087	BLCA	ICGC	PADTPEPT	DEG_SCF_FBW7_1	0.2778
p.A494S	DO229027	LICA	ICGC	PADTPEPT	DEG_SCF_FBW7_1	0.3056
p.A496E	SIDM00555	Glioblastoma	GDSC	PADTPEPT	DEG_SCF_FBW7_1	0.659
p.A496E	ACH-000631	Brain Cancer	CCLE	PADTPEPT	DEG_SCF_FBW7_1	0.659
p.A496E	KS-1	central_nervous_system	COSMIC	PADTPEPT	DEG_SCF_FBW7_1	0.659
p.V496I	Ca9-22	upper_aerodigestive_tract	COSMIC	PADTPEPT	DEG_SCF_FBW7_1	0.7076
p.G508V	NCI-H1703	lung	COSMIC	PADTPEPT	DEG_SCF_FBW7_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBG7	T-lymphocyte surface antigen Ly-9	DEG_SCF_FBW7_1	495:502	PADTPEPT	FBXW7	0.913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons