DegronMD - Q9HBG7(LY9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y589H	TCGA-78-7162	LUAD	TCGA	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.7229
p.Y589H	DO25917	LUAD	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.7229
p.P485S	TCGA-BF-A5EQ	SKCM	TCGA	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.0556
p.P485S	DO222875	MELA	ICGC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.0556
p.P485S	DO219452	SKCM	ICGC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.0556
p.T591M	TCGA-BG-A222	UCEC	TCGA	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.7423
p.T591M	DO42977	UCEC	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.7423
p.E592D	TCGA-D7-A4Z0	STAD	TCGA	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.3056
p.E592D	DO50450	ESAD	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.3056
p.E592D	DO47765	STAD	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.3056
p.P585S	TCGA-DA-A960	SKCM	TCGA	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.6752
p.P585S	DO222875	MELA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.6752
p.P585S	DO219482	SKCM	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.6752
p.S512Y	TCGA-DU-7298	LGG	TCGA	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation blocking phosphorylation signal	0.5
p.S512Y	DO22679	LGG	ICGC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation blocking phosphorylation signal	0.5
p.P588L	TCGA-WE-A8ZY	SKCM	TCGA	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.7582
p.P588L	DO220862	MELA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.7582
p.P588L	DO51292	SKCM	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.7582
p.E493K	TCGA-ZF-AA4V	BLCA	TCGA	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.2778
p.E493K	DO219087	BLCA	ICGC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.2778
p.V590A	DO227906	COCA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.5825
p.G579S	DO233676	GACA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1667
p.A494S	DO229027	LICA	ICGC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.3056
p.S595F	DO222837	MELA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.2222
p.A496E	SIDM00555	Glioblastoma	GDSC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.659
p.A496E	ACH-000631	Brain Cancer	CCLE	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.659
p.A496E	KS-1	central nervous system	COSMIC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.659
p.V586I	SIDM00489	Oral Cavity Carcinoma	GDSC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.5965
p.V586I	ACH-002043	Head and Neck Cancer	CCLE	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.5965
p.V586I	Ca9-22	upper aerodigestive tract	COSMIC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.5965
p.G598V	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1389
p.G598V	ACH-000747	Lung Cancer	CCLE	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1389
p.G598V	NCI-H1703	lung	COSMIC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1389
p.A576V	SIDM00228	Thyroid Gland Carcinoma	GDSC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.0833
p.A576V	ACH-000897	Thyroid Cancer	CCLE	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.0833
p.E578D	ACH-001664	Gastric Cancer	CCLE	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1389
p.V496I	Ca9-22	upper aerodigestive tract	COSMIC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.7076
p.G508V	NCI-H1703	lung	COSMIC	PADTPEPT	DEG_SCF_FBW7_1	495:502	Mutation blocking phosphorylation signal	0.6111
p.G584V	NCI-H1703	lung	COSMIC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.3056
p.Q596H	TE-4	oesophagus	COSMIC	PVTPYVT	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1944

Kaplan plot for LY9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LY9

UniProt ID: Q9HBG7

Entrez ID: 4063

Protein name: T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LY9 in