DegronMD

Uniprot ID: Q9HBG7

Source protein: T-lymphocyte surface antigen Ly-9

Source gene: LY9

Class: DEG_SCF_FBW7_1

Location: 585:591

E3 ligase: FBXW7

DEGRON score: 0.8352

ASA_SCORE: 67.5143

COIL: 0.4731

CONS_SCORE: 0.4226

DSS_SCORE: 0.5326

HELIX: 0.0387

FCONS_SCORE: 0.9342

RIG_SCORE: 0.7848

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y589H	TCGA-78-7162	LUAD	TCGA	PVTPYVT	DEG_SCF_FBW7_1	0.7229
p.Y589H	DO25917	LUAD	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.7229
p.T591M	TCGA-BG-A222	UCEC	TCGA	PVTPYVT	DEG_SCF_FBW7_1	0.7423
p.T591M	DO42977	UCEC	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.7423
p.E592D	TCGA-D7-A4Z0	STAD	TCGA	PVTPYVT	DEG_SCF_FBW7_1	0.3056
p.E592D	DO50450	ESAD	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.3056
p.E592D	DO47765	STAD	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.3056
p.P585S	TCGA-DA-A960	SKCM	TCGA	PVTPYVT	DEG_SCF_FBW7_1	0.6752
p.P585S	DO222875	MELA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.6752
p.P585S	DO219482	SKCM	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.6752
p.P588L	TCGA-WE-A8ZY	SKCM	TCGA	PVTPYVT	DEG_SCF_FBW7_1	0.7582
p.P588L	DO220862	MELA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.7582
p.P588L	DO51292	SKCM	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.7582
p.V590A	DO227906	COCA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.5825
p.G579S	DO233676	GACA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.1667
p.S595F	DO222837	MELA	ICGC	PVTPYVT	DEG_SCF_FBW7_1	0.2222
p.V586I	SIDM00489	Oral Cavity Carcinoma	GDSC	PVTPYVT	DEG_SCF_FBW7_1	0.5965
p.V586I	ACH-002043	Head and Neck Cancer	CCLE	PVTPYVT	DEG_SCF_FBW7_1	0.5965
p.V586I	Ca9-22	upper_aerodigestive_tract	COSMIC	PVTPYVT	DEG_SCF_FBW7_1	0.5965
p.G598V	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PVTPYVT	DEG_SCF_FBW7_1	0.1389
p.G598V	ACH-000747	Lung Cancer	CCLE	PVTPYVT	DEG_SCF_FBW7_1	0.1389
p.G598V	NCI-H1703	lung	COSMIC	PVTPYVT	DEG_SCF_FBW7_1	0.1389
p.A576V	SIDM00228	Thyroid Gland Carcinoma	GDSC	PVTPYVT	DEG_SCF_FBW7_1	0.0833
p.A576V	ACH-000897	Thyroid Cancer	CCLE	PVTPYVT	DEG_SCF_FBW7_1	0.0833
p.E578D	ACH-001664	Gastric Cancer	CCLE	PVTPYVT	DEG_SCF_FBW7_1	0.1389
p.G584V	NCI-H1703	lung	COSMIC	PVTPYVT	DEG_SCF_FBW7_1	0.3056
p.Q596H	TE-4	oesophagus	COSMIC	PVTPYVT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBG7	T-lymphocyte surface antigen Ly-9	DEG_SCF_FBW7_1	585:591	PVTPYVT	FBXW7	0.8352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTPYVT

Degron related mutations and impact score

Drug responses associated with LY9 mutations

All proteins holding degron of PVTPYVT