DegronMD

Uniprot ID: Q8IXI1

Source protein: Mitochondrial Rho GTPase 2

Source gene: RHOT2

Class: DEG_SCF_SKP2-CKS1_1

Location: 43:50

E3 ligase: SKP2,CSK1

DEGRON score: 0.8631

ASA_SCORE: 68.95

COIL: 0.6606

CONS_SCORE: 0.6053

DSS_SCORE: 0.528

HELIX: 0.0315

FCONS_SCORE: 0.9944

RIG_SCORE: 0.7142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P48Q	TCGA-CX-7219	HNSC	TCGA	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.7035
p.P48Q	DO14910	HNSC	ICGC	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.7035
p.P52H	TCGA-EE-A17Y	SKCM	TCGA	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P52H	DO47459	SKCM	ICGC	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E39D	TCGA-IB-7651	PAAD	TCGA	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E39D	DO46657	PAAD	ICGC	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.A44E	SIDM00241	Breast Carcinoma	GDSC	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.659
p.A44E	ACH-002179	Breast Cancer	CCLE	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.659
p.A44E	OCUB-M	breast	COSMIC	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.659
p.T41P	ACH-002247	Non-Cancerous	CCLE	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.T41P	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	PADVTPEK	DEG_SCF_SKP2-CKS1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXI1	Mitochondrial Rho GTPase 2	DEG_SCF_SKP2-CKS1_1	43:50	PADVTPEK	SKP2,CSK1	0.8631	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons