DegronMD

Uniprot ID: Q8NET8

Source protein: Transient receptor potential cation channel subfamily V member 3

Source gene: TRPV3

Class: DEG_SCF_SKP2-CKS1_1

Location: 31:38

E3 ligase: SKP2,CSK1

DEGRON score: 0.9759

ASA_SCORE: 72.9375

COIL: 0.5681

CONS_SCORE: 0.5308

DSS_SCORE: 0.5186

HELIX: 0.3941

FCONS_SCORE: 1.0191

RIG_SCORE: 0.7048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A41T	TCGA-2W-A8YY	CESC	TCGA	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.A41T	DO223732	CESC	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.P31Q	TCGA-95-7043	LUAD	TCGA	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.5924
p.P31Q	DO24739	LUAD	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.5924
p.P31L	TCGA-AA-3877	COAD	TCGA	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.6471
p.P31L	DO7855	COAD	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.6471
p.P31L	SIDM01176	B-Lymphoblastic Leukemia	GDSC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.6471
p.P31L	ACH-000059	Leukemia	CCLE	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.6471
p.P31L	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.6471
p.E46Q	TCGA-EI-6506	READ	TCGA	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E46Q	DO36780	READ	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.S40I	TCGA-EO-A22U	UCEC	TCGA	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.S40I	DO43755	UCEC	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.I25V	DO229010	COCA	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.I25V	DO229013	COCA	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.I25V	DO229016	COCA	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.I25V	DO229003	COCA	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.I25V	DO229005	COCA	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P36L	DO50970	LICA	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.7582
p.E46K	DO222420	MELA	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P31R	DO232861	NACA	ICGC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.6401
p.P31T	SIDM00068	Colorectal Carcinoma	GDSC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.5919
p.P31T	ACH-002394	Colon/Colorectal Cancer	CCLE	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.5919
p.P31T	GEO	large_intestine	COSMIC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.5919
p.P38L	HCT-15	large_intestine	COSMIC	PAEITPTK	DEG_SCF_SKP2-CKS1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NET8	Transient receptor potential cation channel subfamily V member 3	DEG_SCF_SKP2-CKS1_1	31:38	PAEITPTK	SKP2,CSK1	0.9759	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAEITPTK

Degron related mutations and impact score

Drug responses associated with TRPV3 mutations

All proteins holding degron of PAEITPTK