DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 741:748

E3 ligase: FBXW7

DEGRON score: 0.918

ASA_SCORE: 82.825

COIL: 0.9629

CONS_SCORE: 0.2701

DSS_SCORE: 0.6655

HELIX: 0.0139

FCONS_SCORE: 0.6354

RIG_SCORE: 0.5447

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E749K	TCGA-D5-6535	COAD	TCGA	PAGTPPGT	DEG_SCF_FBW7_1	0.3056
p.N732S	TCGA-DF-A2KU	UCEC	TCGA	PAGTPPGT	DEG_SCF_FBW7_1	0.1944
p.G736E	TCGA-G2-AA3B	BLCA	TCGA	PAGTPPGT	DEG_SCF_FBW7_1	0.1944
p.D752Y	DO219209	LUSC	ICGC	PAGTPPGT	DEG_SCF_FBW7_1	0.2222
p.P731S	DO37758	SKCM	ICGC	PAGTPPGT	DEG_SCF_FBW7_1	0.0556
p.D752G	DO38723	STAD	ICGC	PAGTPPGT	DEG_SCF_FBW7_1	0.2222
p.I754S	DO41361	UCEC	ICGC	PAGTPPGT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	741:748	PAGTPPGT	FBXW7	0.918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons