DegronMD

Uniprot ID: Q8WVT3

Source protein: Trafficking protein particle complex subunit 12

Source gene: TRAPPC12

Class: DEG_SCF_FBW7_1

Location: 104:111

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 76.7875

COIL: 0.9561

CONS_SCORE: 0.2623

DSS_SCORE: 0.9321

HELIX: 0.018

FCONS_SCORE: 1.0618

RIG_SCORE: 0.4745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G95E	DO224847	BRCA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.0833
p.G95E	DO227473	BRCA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.0833
p.E121K	DO223051	ESCA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.0556
p.E121K	DO49178	PACA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.0556
p.R97H	DO233156	GACA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.1389
p.G116C	DO228770	LICA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.1944
p.A105V	DO44802	LICA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.5825
p.A105V	ACH-000961	Endometrial/Uterine Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	0.5825
p.D115N	DO224610	LUSC	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.2222
p.P108S	DO220859	MELA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.6752
p.P108S	ACH-000423	Skin Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	0.6752
p.P110S	DO220877	MELA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	0.5641
p.R98H	SIDM00148	Breast Carcinoma	GDSC	PAGTPSPS	DEG_SCF_FBW7_1	0.1667
p.P103L	SIDM00217	Colorectal Carcinoma	GDSC	PAGTPSPS	DEG_SCF_FBW7_1	0.3056
p.P101L	SIDM00479	Esophageal Carcinoma	GDSC	PAGTPSPS	DEG_SCF_FBW7_1	0.25
p.P102L	ACH-000881	Skin Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	0.2778
p.G101D	ACH-000946	Endometrial/Uterine Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	0.25
p.A119T	ACH-000997	Colon/Colorectal Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	0.1111
p.A119T	ACH-001061	Colon/Colorectal Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVT3	Trafficking protein particle complex subunit 12	DEG_SCF_FBW7_1	104:111	PAGTPSPS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons