DegronMD - Q8WVT3(TRAPPC12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V333M	TCGA-5L-AAT1	BRCA	TCGA	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6097
p.V333M	DO219594	BRCA	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6097
p.V333M	SIDM01086	B-Lymphoblastic Leukemia	GDSC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6097
p.V333M	ACH-000874	Leukemia	CCLE	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6097
p.V333M	RS4-11	haematopoietic and lymphoid tissue	COSMIC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6097
p.T325A	TCGA-AX-A2HJ	UCEC	TCGA	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.25
p.T325A	DO42105	UCEC	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.25
p.R321Q	TCGA-B8-5163	KIRC	TCGA	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.1389
p.R321Q	DO18978	KIRC	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.1389
p.L338F	TCGA-D6-6516	HNSC	TCGA	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.2222
p.L338F	DO15623	HNSC	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.2222
p.G95E	DO224847	BRCA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0833
p.G95E	DO227473	BRCA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0833
p.E121K	DO223051	ESCA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0556
p.E121K	DO49178	PACA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0556
p.R97H	DO233156	GACA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1389
p.G116C	DO228770	LICA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1944
p.G329D	DO50970	LICA	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6087
p.A105V	DO44802	LICA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.5825
p.A105V	ACH-000961	Endometrial/Uterine Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.5825
p.D115N	DO224610	LUSC	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.2222
p.P108S	DO220859	MELA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.6752
p.P108S	ACH-000423	Skin Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.6752
p.P110S	DO220877	MELA	ICGC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.5641
p.R328C	DO228138	PBCA	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.8301
p.R321W	SIDM00216	Colorectal Carcinoma	GDSC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.1389
p.R321W	ACH-000989	Colon/Colorectal Cancer	CCLE	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.1389
p.R321W	SNU-175	large intestine	COSMIC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.1389
p.R98H	SIDM00148	Breast Carcinoma	GDSC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1667
p.P103L	SIDM00217	Colorectal Carcinoma	GDSC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.3056
p.P101L	SIDM00479	Esophageal Carcinoma	GDSC	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.25
p.P102L	ACH-000881	Skin Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.2778
p.G101D	ACH-000946	Endometrial/Uterine Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.25
p.A119T	ACH-000997	Colon/Colorectal Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1111
p.A119T	ACH-001061	Colon/Colorectal Cancer	CCLE	PAGTPSPS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1111
p.R328H	ACH-001369	Ovarian Cancer	CCLE	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.8244
p.V319I	ACH-001515	Cervical Cancer	CCLE	RGAVFVD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.0833

Kaplan plot for TRAPPC12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRAPPC12

UniProt ID: Q8WVT3

Entrez ID: 51112

Protein name: Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRAPPC12 in