DegronMD

Uniprot ID: Q8WVT3

Source protein: Trafficking protein particle complex subunit 12

Source gene: TRAPPC12

Class: LIG_APCC_ABBAyCdc20_2

Location: 328:334

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.937

ASA_SCORE: 71.3

COIL: 0.8213

CONS_SCORE: 0.3241

DSS_SCORE: 0.3029

HELIX: 0.049

FCONS_SCORE: 0.8589

RIG_SCORE: 0.8343

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V333M	TCGA-5L-AAT1	BRCA	TCGA	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V333M	DO219594	BRCA	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V333M	SIDM01086	B-Lymphoblastic Leukemia	GDSC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V333M	ACH-000874	Leukemia	CCLE	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V333M	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.T325A	TCGA-AX-A2HJ	UCEC	TCGA	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.T325A	DO42105	UCEC	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.25
p.R321Q	TCGA-B8-5163	KIRC	TCGA	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R321Q	DO18978	KIRC	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L338F	TCGA-D6-6516	HNSC	TCGA	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.L338F	DO15623	HNSC	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G329D	DO50970	LICA	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.6087
p.R328C	DO228138	PBCA	ICGC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R321W	SIDM00216	Colorectal Carcinoma	GDSC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R321W	ACH-000989	Colon/Colorectal Cancer	CCLE	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R321W	SNU-175	large_intestine	COSMIC	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R328H	ACH-001369	Ovarian Cancer	CCLE	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.8244
p.V319I	ACH-001515	Cervical Cancer	CCLE	RGAVFVD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVT3	Trafficking protein particle complex subunit 12	LIG_APCC_ABBAyCdc20_2	328:334	RGAVFVD	APC,CDC20,FZR1	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons