DegronMD

Uniprot ID: Q96HD9

Source protein: N-acyl-aromatic-L-amino acid amidohydrolase

Source gene: ACY3

Class: DEG_SCF_FBW7_1

Location: 309:316

E3 ligase: FBXW7

DEGRON score: 0.5859

ASA_SCORE: 92.625

COIL: 0.9398

CONS_SCORE: 0.2894

DSS_SCORE: 0.5189

HELIX: 0.0105

FCONS_SCORE: 0.7594

RIG_SCORE: 0.7032

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A307V	TCGA-17-Z031	LUAD	TCGA	PALTPAPS	DEG_SCF_FBW7_1	0.2778
p.A310T	TCGA-A8-A09Z	BRCA	TCGA	PALTPAPS	DEG_SCF_FBW7_1	0.6028
p.A310T	SIDM01201	Other Blood Cancers	GDSC	PALTPAPS	DEG_SCF_FBW7_1	0.6028
p.A310T	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	PALTPAPS	DEG_SCF_FBW7_1	0.6028
p.P309T	TCGA-CV-6935	HNSC	TCGA	PALTPAPS	DEG_SCF_FBW7_1	0.7031
p.V305M	TCGA-EE-A2MF	SKCM	TCGA	PALTPAPS	DEG_SCF_FBW7_1	0.2222
p.V305M	SIDM00881	Breast Carcinoma	GDSC	PALTPAPS	DEG_SCF_FBW7_1	0.2222
p.V305M	HCC1428	breast	COSMIC	PALTPAPS	DEG_SCF_FBW7_1	0.2222
p.P309L	SIDM00007	Other Solid Cancers	GDSC	PALTPAPS	DEG_SCF_FBW7_1	0.6471
p.P309L	MCC13	skin	COSMIC	PALTPAPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HD9	N-acyl-aromatic-L-amino acid amidohydrolase	DEG_SCF_FBW7_1	309:316	PALTPAPS	FBXW7	0.5859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons