DegronMD - Q96HD9(ACY3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A307V	TCGA-17-Z031	LUAD	TCGA	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2778
p.A310T	TCGA-A8-A09Z	BRCA	TCGA	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6028
p.A310T	SIDM01201	Other Blood Cancers	GDSC	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6028
p.A310T	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6028
p.P10S	TCGA-AA-3510	COAD	TCGA	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.5641
p.P10S	DO7783	COAD	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.5641
p.R13H	TCGA-BS-A0UV	UCEC	TCGA	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7133
p.R13H	DO42793	UCEC	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7133
p.P309T	TCGA-CV-6935	HNSC	TCGA	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7031
p.V305M	TCGA-EE-A2MF	SKCM	TCGA	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2222
p.V305M	SIDM00881	Breast Carcinoma	GDSC	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2222
p.V305M	HCC1428	breast	COSMIC	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2222
p.R8Q	DO229013	COCA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7329
p.R8Q	DO229016	COCA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7329
p.R8Q	DO229003	COCA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7329
p.R8Q	DO229005	COCA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7329
p.R20H	DO12250	GBM	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.1944
p.E12K	DO13863	GBM	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7022
p.E12K	ACH-001578	Embryonal Cancer	CCLE	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7022
p.E12K	NCCIT	testis	COSMIC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7022
p.A7V	DO49775	KIRP	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.6936
p.P5H	DO228985	LICA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2778
p.H11N	DO229015	LICA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.7423
p.L4M	DO229034	LICA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.25
p.R13S	DO229041	LICA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation altering degron motif	0.6316
p.C19Y	DO45013	LIHC	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.2222
p.I6T	DO32646	OV	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.3056
p.P309L	SIDM00007	Other Solid Cancers	GDSC	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6471
p.P309L	MCC13	skin	COSMIC	PALTPAPS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6471
p.E24K	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0833
p.E24K	ACH-000852	Lung Cancer	CCLE	PREPLRRVA	DEG_APCC_DBOX_1	7:15	Mutation rewiring degron network	0.0833

Kaplan plot for ACY3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACY3

UniProt ID: Q96HD9

Entrez ID: 91703

Protein name: N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase-3) (ACY-3) (Aspartoacylase-2) (Hepatitis C virus core-binding protein 1) (HCBP1) (HCV core-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACY3 in