DegronMD

Uniprot ID: Q96HD9

Source protein: N-acyl-aromatic-L-amino acid amidohydrolase

Source gene: ACY3

Class: DEG_APCC_DBOX_1

Location: 7:15

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8846

ASA_SCORE: 77.9111

COIL: 0.6363

CONS_SCORE: 0.4876

DSS_SCORE: 0.4728

HELIX: 0.013

FCONS_SCORE: 0.7496

RIG_SCORE: 0.7672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P10S	TCGA-AA-3510	COAD	TCGA	PREPLRRVA	DEG_APCC_DBOX_1	0.5641
p.P10S	DO7783	COAD	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.5641
p.R13H	TCGA-BS-A0UV	UCEC	TCGA	PREPLRRVA	DEG_APCC_DBOX_1	0.7133
p.R13H	DO42793	UCEC	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.7133
p.R8Q	DO229013	COCA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.7329
p.R8Q	DO229016	COCA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.7329
p.R8Q	DO229003	COCA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.7329
p.R8Q	DO229005	COCA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.7329
p.R20H	DO12250	GBM	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.1944
p.E12K	DO13863	GBM	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.7022
p.E12K	ACH-001578	Embryonal Cancer	CCLE	PREPLRRVA	DEG_APCC_DBOX_1	0.7022
p.E12K	NCCIT	testis	COSMIC	PREPLRRVA	DEG_APCC_DBOX_1	0.7022
p.A7V	DO49775	KIRP	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.6936
p.P5H	DO228985	LICA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.2778
p.H11N	DO229015	LICA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.7423
p.L4M	DO229034	LICA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.25
p.R13S	DO229041	LICA	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.6316
p.C19Y	DO45013	LIHC	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.2222
p.I6T	DO32646	OV	ICGC	PREPLRRVA	DEG_APCC_DBOX_1	0.3056
p.E24K	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PREPLRRVA	DEG_APCC_DBOX_1	0.0833
p.E24K	ACH-000852	Lung Cancer	CCLE	PREPLRRVA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HD9	N-acyl-aromatic-L-amino acid amidohydrolase	DEG_APCC_DBOX_1	7:15	PREPLRRVA	APC,CDC20,FZR1	0.8846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons