DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1080:1087

E3 ligase: FBXW7

DEGRON score: 0.8796

ASA_SCORE: 84.3875

COIL: 0.9596

CONS_SCORE: 0.3977

DSS_SCORE: 0.6875

HELIX: 0.0113

FCONS_SCORE: 0.9115

RIG_SCORE: 0.6128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1081T	TCGA-AJ-A8CT	UCEC	TCGA	PALTPEPS	DEG_SCF_FBW7_1	0.6028
p.A1081T	DO52399	UCEC	ICGC	PALTPEPS	DEG_SCF_FBW7_1	0.6028
p.P1095L	TCGA-XR-A8TD	LIHC	TCGA	PALTPEPS	DEG_SCF_FBW7_1	0.1111
p.P1095L	DO223921	LIHC	ICGC	PALTPEPS	DEG_SCF_FBW7_1	0.1111
p.P1086L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PALTPEPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1080:1087	PALTPEPS	FBXW7	0.8796	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons