DegronMD

Uniprot ID: Q5T6C5

Source protein: Ataxin-7-like protein 2

Source gene: ATXN7L2

Class: DEG_SCF_FBW7_1

Location: 537:544

E3 ligase: FBXW7

DEGRON score: 0.9875

ASA_SCORE: 84.9875

COIL: 0.9489

CONS_SCORE: 0.3744

DSS_SCORE: 0.6233

HELIX: 0.0331

FCONS_SCORE: 0.958

RIG_SCORE: 0.5952

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A553D	TCGA-19-5956	GBM	TCGA	PANTPSPS	DEG_SCF_FBW7_1	0.0833
p.A553D	DO13863	GBM	ICGC	PANTPSPS	DEG_SCF_FBW7_1	0.0833
p.K552N	TCGA-B5-A1MX	UCEC	TCGA	PANTPSPS	DEG_SCF_FBW7_1	0.2222
p.K552N	DO41999	UCEC	ICGC	PANTPSPS	DEG_SCF_FBW7_1	0.2222
p.T540M	TCGA-DF-A2KU	UCEC	TCGA	PANTPSPS	DEG_SCF_FBW7_1	0.7423
p.T540M	DO223286	UCEC	ICGC	PANTPSPS	DEG_SCF_FBW7_1	0.7423
p.S534L	TCGA-E9-A3QA	BRCA	TCGA	PANTPSPS	DEG_SCF_FBW7_1	0.25
p.S534L	DO44268	BRCA	ICGC	PANTPSPS	DEG_SCF_FBW7_1	0.25
p.P549L	DO234407	ESAD	ICGC	PANTPSPS	DEG_SCF_FBW7_1	0.1944
p.P535S	DO234401	ESAD	ICGC	PANTPSPS	DEG_SCF_FBW7_1	0.2778
p.P549T	SIDM00836	Colorectal Carcinoma	GDSC	PANTPSPS	DEG_SCF_FBW7_1	0.1944
p.P549T	ACH-000820	Colon/Colorectal Cancer	CCLE	PANTPSPS	DEG_SCF_FBW7_1	0.1944
p.P549T	SW403	large_intestine	COSMIC	PANTPSPS	DEG_SCF_FBW7_1	0.1944
p.S542F	SIDM00655	Other Solid Cancers	GDSC	PANTPSPS	DEG_SCF_FBW7_1	0.6871
p.S542F	ACH-001578	Embryonal Cancer	CCLE	PANTPSPS	DEG_SCF_FBW7_1	0.6871
p.S542F	NCCIT	testis	COSMIC	PANTPSPS	DEG_SCF_FBW7_1	0.6871
p.P543L	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PANTPSPS	DEG_SCF_FBW7_1	0.6471
p.P543L	ACH-000106	Lymphoma	CCLE	PANTPSPS	DEG_SCF_FBW7_1	0.6471
p.P543L	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PANTPSPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T6C5	Ataxin-7-like protein 2	DEG_SCF_FBW7_1	537:544	PANTPSPS	FBXW7	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons