DegronMD - Q5T6C5(ATXN7L2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P499L	TCGA-13-0726	OV	TCGA	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.2778
p.P499L	DO28373	OV	ICGC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.2778
p.A553D	TCGA-19-5956	GBM	TCGA	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.0833
p.A553D	DO13863	GBM	ICGC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.0833
p.K552N	TCGA-B5-A1MX	UCEC	TCGA	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation substituting flanking lysine	0.2222
p.K552N	DO41999	UCEC	ICGC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation substituting flanking lysine	0.2222
p.T540M	TCGA-DF-A2KU	UCEC	TCGA	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation altering degron motif	0.7423
p.T540M	DO223286	UCEC	ICGC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation altering degron motif	0.7423
p.S534L	TCGA-E9-A3QA	BRCA	TCGA	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.25
p.S534L	DO44268	BRCA	ICGC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.25
p.P549L	DO234407	ESAD	ICGC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1944
p.P535S	DO234401	ESAD	ICGC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.2778
p.V516L	DO229045	LICA	ICGC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1389
p.P514L	DO220896	MELA	ICGC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1944
p.P495S	SIDM01265	Plasma Cell Myeloma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00773	Non-Cancerous	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00845	Burkitt's Lymphoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00967	Ovarian Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00969	Ovarian Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM01126	Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM01112	Osteosarcoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00529	Breast Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00650	Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM01681	Non-Cancerous	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00721	Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM00774	Breast Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM01140	Ovarian Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM01664	Prostate Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM01752	Pancreatic Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P495S	SIDM01525	Acute Myeloid Leukemia	GDSC	TKDNLVPSY	DEG_COP1_1	501:509	Mutation rewiring degron network	0.1667
p.P549T	SIDM00836	Colorectal Carcinoma	GDSC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1944
p.P549T	ACH-000820	Colon/Colorectal Cancer	CCLE	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1944
p.P549T	SW403	large intestine	COSMIC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation rewiring degron network	0.1944
p.S542F	SIDM00655	Other Solid Cancers	GDSC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation altering degron motif	0.6871
p.S542F	ACH-001578	Embryonal Cancer	CCLE	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation altering degron motif	0.6871
p.S542F	NCCIT	testis	COSMIC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation altering degron motif	0.6871
p.P543L	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation altering degron motif	0.6471
p.P543L	ACH-000106	Lymphoma	CCLE	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation altering degron motif	0.6471
p.P543L	JVM-2	haematopoietic and lymphoid tissue	COSMIC	PANTPSPS	DEG_SCF_FBW7_1	537:544	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN7L2

UniProt ID: Q5T6C5

Entrez ID: 127002

Protein name: Ataxin-7-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATXN7L2 in