DegronMD

Uniprot ID: Q5T6C5

Source protein: Ataxin-7-like protein 2

Source gene: ATXN7L2

Class: DEG_COP1_1

Location: 501:509

E3 ligase: COP1

DEGRON score: 0.8536

ASA_SCORE: 96.5222

COIL: 0.9134

CONS_SCORE: 0.4197

DSS_SCORE: 0.5178

HELIX: 0.0369

FCONS_SCORE: 1.045

RIG_SCORE: 0.6871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P499L	TCGA-13-0726	OV	TCGA	TKDNLVPSY	DEG_COP1_1	0.2778
p.P499L	DO28373	OV	ICGC	TKDNLVPSY	DEG_COP1_1	0.2778
p.V516L	DO229045	LICA	ICGC	TKDNLVPSY	DEG_COP1_1	0.1389
p.P514L	DO220896	MELA	ICGC	TKDNLVPSY	DEG_COP1_1	0.1944
p.P495S	SIDM01265	Plasma Cell Myeloma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00773	Non-Cancerous	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00845	Burkitt's Lymphoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00967	Ovarian Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00969	Ovarian Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM01126	Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM01112	Osteosarcoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00529	Breast Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00650	Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00431	T-Lymphoblastic Leukemia	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM01681	Non-Cancerous	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00721	Small Cell Lung Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM00774	Breast Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM01140	Ovarian Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM01664	Prostate Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM01752	Pancreatic Carcinoma	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667
p.P495S	SIDM01525	Acute Myeloid Leukemia	GDSC	TKDNLVPSY	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T6C5	Ataxin-7-like protein 2	DEG_COP1_1	501:509	TKDNLVPSY	COP1	0.8536	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TKDNLVPSY

Degron related mutations and impact score

Drug responses associated with ATXN7L2 mutations

All proteins holding degron of TKDNLVPSY