DegronMD

Uniprot ID: P33402

Source protein: Guanylate cyclase soluble subunit alpha-2

Source gene: GUCY1A2

Class: DEG_SCF_FBW7_1

Location: 59:66

E3 ligase: FBXW7

DEGRON score: 0.6038

ASA_SCORE: 80.8125

COIL: 0.666

CONS_SCORE: 0.3679

DSS_SCORE: 0.4209

HELIX: 0.3295

FCONS_SCORE: 1.0245

RIG_SCORE: 0.6379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A64V	DO222765	COCA	ICGC	PAPTPAAS	DEG_SCF_FBW7_1	0.5825
p.A68T	DO234360	ESAD	ICGC	PAPTPAAS	DEG_SCF_FBW7_1	0.2778
p.A55T	DO233737	GACA	ICGC	PAPTPAAS	DEG_SCF_FBW7_1	0.2222
p.T62P	DO219881	SKCA	ICGC	PAPTPAAS	DEG_SCF_FBW7_1	0.7031
p.G75R	SIDM02026	Colorectal Carcinoma	GDSC	PAPTPAAS	DEG_SCF_FBW7_1	0.0833
p.P50L	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	PAPTPAAS	DEG_SCF_FBW7_1	0.0833
p.P50L	SIDM01726	Ewing's Sarcoma	GDSC	PAPTPAAS	DEG_SCF_FBW7_1	0.0833
p.A67V	ACH-001617	Lymphoma	CCLE	PAPTPAAS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33402	Guanylate cyclase soluble subunit alpha-2	DEG_SCF_FBW7_1	59:66	PAPTPAAS	FBXW7	0.6038	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons