DegronMD - P33402(GUCY1A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R84W	TCGA-BR-8588	STAD	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.8634
p.R84W	DO47855	STAD	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.8634
p.R81H	TCGA-BR-8680	STAD	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.2778
p.R81H	DO47769	STAD	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.2778
p.S101L	TCGA-DK-A3WW	BLCA	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.0556
p.S101L	DO481	BLCA	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.0556
p.S101L	SIDM01036	Plasma Cell Myeloma	GDSC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.0556
p.S101W	TCGA-FD-A43X	BLCA	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.0556
p.S101W	DO44067	BLCA	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.0556
p.R77S	TCGA-HD-7229	HNSC	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1667
p.R77S	DO15479	HNSC	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1667
p.A64V	DO222765	COCA	ICGC	PAPTPAAS	DEG_SCF_FBW7_1	59:66	Mutation altering degron motif	0.5825
p.A68T	DO234360	ESAD	ICGC	PAPTPAAS	DEG_SCF_FBW7_1	59:66	Mutation rewiring degron network	0.2778
p.A55T	DO233737	GACA	ICGC	PAPTPAAS	DEG_SCF_FBW7_1	59:66	Mutation rewiring degron network	0.2222
p.R96H	DO233837	GACA	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1944
p.R96S	DO229038	LICA	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1944
p.T62P	DO219881	SKCA	ICGC	PAPTPAAS	DEG_SCF_FBW7_1	59:66	Mutation altering degron motif	0.7031
p.G75R	SIDM02026	Colorectal Carcinoma	GDSC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1111
p.G75R	SIDM02026	Colorectal Carcinoma	GDSC	PAPTPAAS	DEG_SCF_FBW7_1	59:66	Mutation rewiring degron network	0.0833
p.L90P	SIDM00373	Endometrial Carcinoma	GDSC	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.7582
p.L90P	ACH-000974	Endometrial/Uterine Cancer	CCLE	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.7582
p.L90P	ACH-002026	Endometrial/Uterine Cancer	CCLE	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation altering degron motif	0.7582
p.P50L	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	PAPTPAAS	DEG_SCF_FBW7_1	59:66	Mutation rewiring degron network	0.0833
p.P50L	SIDM01726	Ewing's Sarcoma	GDSC	PAPTPAAS	DEG_SCF_FBW7_1	59:66	Mutation rewiring degron network	0.0833
p.T98M	ACH-000997	Colon/Colorectal Cancer	CCLE	RRVNLDSLG	DEG_APCC_DBOX_1	83:91	Mutation rewiring degron network	0.1389
p.A67V	ACH-001617	Lymphoma	CCLE	PAPTPAAS	DEG_SCF_FBW7_1	59:66	Mutation rewiring degron network	0.3056

Kaplan plot for GUCY1A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GUCY1A2

UniProt ID: P33402

Entrez ID: 2977

Protein name: Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GUCY1A2 in