DegronMD

Uniprot ID: P33402

Source protein: Guanylate cyclase soluble subunit alpha-2

Source gene: GUCY1A2

Class: DEG_APCC_DBOX_1

Location: 83:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9873

ASA_SCORE: 62.9222

COIL: 0.4318

CONS_SCORE: 0.4541

DSS_SCORE: 0.4793

HELIX: 0.5167

FCONS_SCORE: 1.1648

RIG_SCORE: 0.7199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R84W	TCGA-BR-8588	STAD	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	0.8634
p.R84W	DO47855	STAD	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	0.8634
p.R81H	TCGA-BR-8680	STAD	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	0.2778
p.R81H	DO47769	STAD	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	0.2778
p.S101L	TCGA-DK-A3WW	BLCA	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	0.0556
p.S101L	DO481	BLCA	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	0.0556
p.S101L	SIDM01036	Plasma Cell Myeloma	GDSC	RRVNLDSLG	DEG_APCC_DBOX_1	0.0556
p.S101W	TCGA-FD-A43X	BLCA	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	0.0556
p.S101W	DO44067	BLCA	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	0.0556
p.R77S	TCGA-HD-7229	HNSC	TCGA	RRVNLDSLG	DEG_APCC_DBOX_1	0.1667
p.R77S	DO15479	HNSC	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	0.1667
p.R96H	DO233837	GACA	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	0.1944
p.R96S	DO229038	LICA	ICGC	RRVNLDSLG	DEG_APCC_DBOX_1	0.1944
p.G75R	SIDM02026	Colorectal Carcinoma	GDSC	RRVNLDSLG	DEG_APCC_DBOX_1	0.1111
p.L90P	SIDM00373	Endometrial Carcinoma	GDSC	RRVNLDSLG	DEG_APCC_DBOX_1	0.7582
p.L90P	ACH-000974	Endometrial/Uterine Cancer	CCLE	RRVNLDSLG	DEG_APCC_DBOX_1	0.7582
p.L90P	ACH-002026	Endometrial/Uterine Cancer	CCLE	RRVNLDSLG	DEG_APCC_DBOX_1	0.7582
p.T98M	ACH-000997	Colon/Colorectal Cancer	CCLE	RRVNLDSLG	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33402	Guanylate cyclase soluble subunit alpha-2	DEG_APCC_DBOX_1	83:91	RRVNLDSLG	APC,CDC20,FZR1	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons