DegronMD

Uniprot ID: Q8N4L8

Source protein: Coiled-coil domain-containing protein 24

Source gene: CCDC24

Class: DEG_SCF_FBW7_1

Location: 293:300

E3 ligase: FBXW7

DEGRON score: 0.8648

ASA_SCORE: 85.3625

COIL: 0.9399

CONS_SCORE: 0.301

DSS_SCORE: 0.7762

HELIX: 0.0323

FCONS_SCORE: 0.9145

RIG_SCORE: 0.5695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G292V	TCGA-GN-A265	SKCM	TCGA	PASTPMSS	DEG_SCF_FBW7_1	0.3056
p.G292V	DO37491	SKCM	ICGC	PASTPMSS	DEG_SCF_FBW7_1	0.3056
p.A305V	DO229013	COCA	ICGC	PASTPMSS	DEG_SCF_FBW7_1	0.1944
p.A305V	DO229016	COCA	ICGC	PASTPMSS	DEG_SCF_FBW7_1	0.1944
p.A305V	DO229003	COCA	ICGC	PASTPMSS	DEG_SCF_FBW7_1	0.1944
p.A305V	DO229480	LAML	ICGC	PASTPMSS	DEG_SCF_FBW7_1	0.1944
p.A305V	DO229489	LAML	ICGC	PASTPMSS	DEG_SCF_FBW7_1	0.1944
p.A305V	DO230522	LUSC	ICGC	PASTPMSS	DEG_SCF_FBW7_1	0.1944
p.A305V	DO230539	LUSC	ICGC	PASTPMSS	DEG_SCF_FBW7_1	0.1944
p.R290S	SIDM01117	Small Cell Lung Carcinoma	GDSC	PASTPMSS	DEG_SCF_FBW7_1	0.25
p.R290S	SIDM00690	Head and Neck Carcinoma	GDSC	PASTPMSS	DEG_SCF_FBW7_1	0.25
p.R290S	SIDM01147	Gastric Carcinoma	GDSC	PASTPMSS	DEG_SCF_FBW7_1	0.25
p.R290S	SIDM00793	Burkitt's Lymphoma	GDSC	PASTPMSS	DEG_SCF_FBW7_1	0.25
p.R290S	SIDM01752	Pancreatic Carcinoma	GDSC	PASTPMSS	DEG_SCF_FBW7_1	0.25
p.R290S	SIDM01525	Acute Myeloid Leukemia	GDSC	PASTPMSS	DEG_SCF_FBW7_1	0.25
p.A305T	SIDM00953	Small Cell Lung Carcinoma	GDSC	PASTPMSS	DEG_SCF_FBW7_1	0.1944
p.A305T	SIDM01322	Oral Cavity Carcinoma	GDSC	PASTPMSS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4L8	Coiled-coil domain-containing protein 24	DEG_SCF_FBW7_1	293:300	PASTPMSS	FBXW7	0.8648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons