DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PATPAAS
Uniprot ID:
Q00888
Source protein:
Pregnancy-specific beta-1-glycoprotein 4
Source gene:
PSG4
Class:
DEG_SCF_FBW7_1
Location:
171:177
E3 ligase:
FBXW7
DEGRON score:
0.8436
ASA_SCORE:
49.7
COIL:
0.7499
CONS_SCORE:
0.2511
DSS_SCORE:
0.1966
HELIX:
0.0139
FCONS_SCORE:
0.5717
RIG_SCORE:
0.7609
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E163D
TCGA-37-5819
LUSC
TCGA
PATPAAS
DEG_SCF_FBW7_1
0.1111
p.E163D
DO26479
LUSC
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.1111
p.A161V
TCGA-39-5034
LUSC
TCGA
PATPAAS
DEG_SCF_FBW7_1
0.0556
p.A161V
DO26854
LUSC
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.0556
p.M162T
TCGA-44-5644
LUAD
TCGA
PATPAAS
DEG_SCF_FBW7_1
0.0833
p.M162T
DO25153
LUAD
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.0833
p.A172V
TCGA-A5-A0G2
UCEC
TCGA
PATPAAS
DEG_SCF_FBW7_1
0.5825
p.A172V
DO41235
UCEC
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.5825
p.E163K
TCGA-CN-A63Y
HNSC
TCGA
PATPAAS
DEG_SCF_FBW7_1
0.1111
p.E163K
DO44422
HNSC
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.1111
p.L167S
TCGA-D8-A147
BRCA
TCGA
PATPAAS
DEG_SCF_FBW7_1
0.2222
p.L167S
DO4347
BRCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.2222
p.D170N
TCGA-EE-A2MR
SKCM
TCGA
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.D170N
DO225232
BRCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.D170N
DO37819
SKCM
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.A176T
TCGA-F4-6460
COAD
TCGA
PATPAAS
DEG_SCF_FBW7_1
0.6028
p.A176T
DO8850
COAD
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.6028
p.K174N
DO51951
BLCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.6918
p.G184C
DO223732
CESC
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.1389
p.K174E
DO229010
COCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.7022
p.K174E
DO229013
COCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.7022
p.K174E
DO229016
COCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.7022
p.K174E
DO229003
COCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.7022
p.K174E
DO229005
COCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.7022
p.G184V
DO234468
ESAD
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.1389
p.E170K
DO15799
HNSC
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.E170K
DO44422
HNSC
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.E170K
DO37635
SKCM
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.E170K
DO37631
SKCM
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.E170K
DO47282
SKCM
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.E170K
DO47268
SKCM
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.E170K
DO37778
SKCM
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.3056
p.W180C
DO229050
LICA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.25
p.T173N
DO229006
LICA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.7055
p.N183S
DO23651
LUAD
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.1667
p.T168S
DO230529
LUSC
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.25
p.T168S
SIDM00570
Gastric Carcinoma
GDSC
PATPAAS
DEG_SCF_FBW7_1
0.25
p.T168S
SIDM00591
Oral Cavity Carcinoma
GDSC
PATPAAS
DEG_SCF_FBW7_1
0.25
p.T168S
SIDM01618
B-Lymphoblastic Leukemia
GDSC
PATPAAS
DEG_SCF_FBW7_1
0.25
p.M162I
DO220889
MELA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.0833
p.G184S
DO222658
MELA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.1389
p.G184S
DO37599
SKCM
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.1389
p.C169W
DO48626
SKCM
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.2778
p.T173I
DO229227
THCA
ICGC
PATPAAS
DEG_SCF_FBW7_1
0.7078
p.S177R
SIDM00703
Non-Small Cell Lung Carcinoma
GDSC
PATPAAS
DEG_SCF_FBW7_1
0.7427
p.Q185H
SIDM00882
Breast Carcinoma
GDSC
PATPAAS
DEG_SCF_FBW7_1
0.1111
p.Q185H
ACH-000277
Breast Cancer
CCLE
PATPAAS
DEG_SCF_FBW7_1
0.1111
p.Q185H
HCC1419
breast
COSMIC
PATPAAS
DEG_SCF_FBW7_1
0.1111
p.P171T
SIDM00160
Biliary Tract Carcinoma
GDSC
PATPAAS
DEG_SCF_FBW7_1
0.7031
p.P171T
ACH-000377
Bile Duct Cancer
CCLE
PATPAAS
DEG_SCF_FBW7_1
0.7031
Drug responses associated with PSG4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PATPAAS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q00888
Pregnancy-specific beta-1-glycoprotein 4
DEG_SCF_FBW7_1
171:177
PATPAAS
FBXW7
0.8436
More...